{
  "abstract": "Flavin–amine interactions are central to neurotransmitter metabolism, yet how H-bonding and amine structure govern excited-state pathways remains unclear. Using lumichrome (LC) as a biomimetic model, we examine interactions and photobehaviour with sympathomimetic amines, norephedrine (Neph), ephedrine (Eph), and pseudoephedrine (Peph). In water, LC with amines readily forms anions. In dichloromethane, H-bonding drives ultrafast single-proton transfer (SPT) in the LC–Neph complex (~800 fs), followed by population redistribution (~14 ps) and a long-lived anion (τ ~5.4 ns), while LC–Eph and LC–Peph complexes show shorter lifetimes (~4.3–4.8 ns). Control experiments with phenethylamine confirm that the amine group drives SPT-mediated anion formation. Computational calculations support excitation-induced charge redistribution and SPT-mediated zwitterionic stabilisation. Nanosecond-millisecond transient absorption shows minor triplet quenching by Neph (τ ~0.74 → 0.66 μs), but Eph and Peph enhance quenching (τ ~0.45-0.55 μs) and photoproduct formation. This study unravels LC–sympathomimetic amine interactions, offering an avenue to interrogate excited-state pathways in flavin photochemistry.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Química Física, Facultad de Ciencias Ambientales y Bioquímica, y INAMOL, Universidad de Castilla-La Mancha, Avenida Carlos III, S/N",
    "Departament de Química, Universitat Autònoma de Barcelona"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Subhrakant Jena"
    },
    {
      "affs": [
        0
      ],
      "name": "Mario de la Hoz Tomás"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Ángel Organero"
    },
    {
      "affs": [
        1
      ],
      "name": "Miquel Moreno Ferrer"
    },
    {
      "affs": [
        0
      ],
      "name": "Abderrazzak Douhal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ec4s7ybwq7hmk.bib",
  "cited_by": 0,
  "doi": "10.1038/s42004-026-02110-7",
  "fulltext_url": "https://doi.org/10.1038/s42004-026-02110-7",
  "id": "ec4s7ybwq7hmk",
  "issns": [
    "2399-3669"
  ],
  "landing_url": "https://doi.org/10.1038/s42004-026-02110-7",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QD1-999"
    ],
    [
      "openalex",
      "1606|Photochemistry and Electron Transfer Studies"
    ]
  ],
  "openalex": "W7166818979",
  "pdf_url": "https://www.nature.com/articles/s42004-026-02110-7_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/ec4s7ybwq7hmk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:41Z",
      "native_id": "0085afd5b2244fee970b3ec0c6e945b3",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s42004-026-02110-7"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1606|Photochemistry and Electron Transfer Studies",
      "subfield": "physical"
    }
  ],
  "title": "Exploring the photodynamical landscape of biomimetic lumichrome–ephedrine-class amine complexes across femtosecond to millisecond regimes",
  "title_text": "Exploring the photodynamical landscape of biomimetic lumichrome–ephedrine-class amine complexes across femtosecond to millisecond regimes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:41Z",
  "url": "https://research.draconitic.com/paper/ec4s7ybwq7hmk",
  "venue": "Communications Chemistry",
  "versions": []
}