{
  "abstract": "As a critical tumor suppressor gene, mutations in p53 often contribute to the initiation and progression of cancer. Anti-p53 autoantibody (p53-AAb), produced by the immune system in response to mutated p53 protein, can be detected in the blood during early stages of tumor development. As a non-invasive biomarker, p53-AAb demonstrates potential for early screening, auxiliary diagnosis, prognosis evaluation, and treatment monitoring across various cancer types. Based on current literature and evidence-based medical data, this Review Article provides an overview of the scientific rationale, technical aspects, and clinical applications of p53-AAb testing. It summarizes practical considerations to guide scientific research and clinical practice, with the aim of promoting standardized utilization of this biomarker.",
  "abstract_shown": true,
  "affiliations": [
    "Zhejiang Cancer Institute, Zhejiang Cancer Hospital",
    "Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine",
    "Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, High-Tech Zone",
    "Department of General Surgery, Taixing People’s Hospital, Yangzhou University",
    "Cell and Molecular Biology Laboratory, Zhoushan Hospital",
    "Department of Medical Oncology, Bozhou Hospital of Traditional Chinese Medicine",
    "Department of Laboratory Medicine, Tongde Hospital of Zhejiang Province",
    "Department of Surgery, Jinhua People’s Hospital, Jindong District",
    "Department of Surgery, Zhejiang Hospital",
    "Department of Molecular Diagnostics, Hangzhou Lianchuan Biotechnology Co."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fan Bu"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhe-Nan Ling"
    },
    {
      "affs": [
        2
      ],
      "name": "Pei Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Bin Zhou"
    },
    {
      "affs": [
        4
      ],
      "name": "Wang-Yu Zhu"
    },
    {
      "affs": [
        5
      ],
      "name": "Jiu-Li Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Xiang Liu"
    },
    {
      "affs": [
        7
      ],
      "name": "Tian-Yu Zhu"
    },
    {
      "affs": [
        8
      ],
      "name": "Yi-An Du"
    },
    {
      "affs": [
        9
      ],
      "name": "Qiu-Lei Lang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liu-Hui Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Zi-Yan Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Wen-Jing Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi-Xuan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu-Zhen Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xia-Ying Du"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhi-Qiang Ling"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/echax91k3px2t.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1910252",
  "fulltext_url": "https://europepmc.org/articles/PMC13681304",
  "id": "echax91k3px2t",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1910252/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer-related Molecular Pathways"
    ]
  ],
  "openalex": "W7220659823",
  "pdf_url": "https://europepmc.org/articles/PMC13681304?pdf=render",
  "pmcid": "PMC13681304",
  "pmid": "42903374",
  "published": "2026-10-06",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/echax91k3px2t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1910252",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1910252/full"
    },
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903374",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903374"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer-related Molecular Pathways",
      "subfield": "oncology"
    }
  ],
  "title": "Review on the significance and clinical application of anti-p53 autoantibody detection",
  "title_text": "Review on the significance and clinical application of anti-p53 autoantibody detection",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/echax91k3px2t",
  "venue": "Frontiers in Immunology",
  "versions": []
}