{
  "abstract": "Microglia closely associate with the vasculature, but their roles in leukocyte trafficking and cerebral blood flow (CBF) during systemic inflammation are unclear. We show that sustained systemic inflammation leads to altered microglia-vascular interactions, leukocyte recruitment to cerebral blood vessels and reduced hypercapnia-induced vasodilation. We find that microglia and border-associated macrophages (BAMs) play distinct roles in these processes: while BAM depletion with clodronate increases leukocyte recruitment, microglia/BAM depletion with PLX5622 and the absence of microglia, but not BAMs in CSF1RΔFIRE/ΔFIRE mice, result in markedly reduced leukocyte recruitment. Supporting this, conditional microglial IL-1 deletion inhibits leukocyte recruitment. Unlike BAM depletion, the absence of microglia impairs hypercapnia-induced vasodilation, while in vivo two-photon imaging reveals microglial IL-1α-dependent interactions between leukocytes and penetrating arteries. Accordingly, reduced hypercapnia-induced vasodilation involves endothelial IL-1R1 and microglial IL-1α. Thus, distinct brain macrophage populations exert opposite effects on leukocyte recruitment and CBF through IL-1 dependent mechanisms in given vascular beds in male mice.",
  "abstract_shown": true,
  "affiliations": [
    "\"Momentum\" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.",
    "János Szentágothai Doctoral School of Neurosciences, Schools of PhD Studies, Semmelweis University, Budapest, Hungary.",
    "Normandie University, Caen Normandie University, UNICAEN, INSERM U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Cyceron, Institut Blood and Brain @ Caen-Normandie (BB@C), Caen, France.",
    "Department of Neuroscience, Yale School of Medicine, Yale University, 333 Cedar Street, New Haven, CT, USA.",
    "Hungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary.",
    "Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.",
    "Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Munster, Germany.",
    "Cells-in-Motion Interfaculty Centre (CIMIC), University of Münster, Münster, Germany.",
    "Centre for Inflammation Research Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.",
    "Department of Clinical Research, Caen University Hospital, Caen, France.",
    "\"Momentum\" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary. denes.adam@koki.hun-ren.hu."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ana Rita Brás",
      "orcid": "0000-0003-4319-7010"
    },
    {
      "affs": [
        0
      ],
      "name": "Nikolett Lénárt",
      "orcid": "0000-0002-7456-949X"
    },
    {
      "affs": [
        2
      ],
      "name": "Damien Levard",
      "orcid": "0000-0002-7275-3170"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Martina Glavan"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Ákos Menyhárt"
    },
    {
      "affs": [
        0
      ],
      "name": "Csaba Cserép"
    },
    {
      "affs": [
        0
      ],
      "name": "Balázs Pósfai",
      "orcid": "0000-0003-1035-565X"
    },
    {
      "affs": [
        0
      ],
      "name": "Eszter Császár"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Sai K Reddy Samawar"
    },
    {
      "affs": [
        8
      ],
      "name": "Clare Pridans",
      "orcid": "0000-0001-9423-557X"
    },
    {
      "affs": [
        2,
        9
      ],
      "name": "Denis Vivien",
      "orcid": "0000-0002-7636-2185"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Eszter Farkas",
      "orcid": "0000-0002-8478-9664"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Lydia Sorokin",
      "orcid": "0000-0001-7704-7921"
    },
    {
      "affs": [
        2
      ],
      "name": "Marina Rubio",
      "orcid": "0000-0002-6120-4053"
    },
    {
      "affs": [
        10
      ],
      "name": "Ádám Dénes",
      "orcid": "0000-0001-6919-4905"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eczwgrjkn6zh9.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77787-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13680361",
  "id": "eczwgrjkn6zh9",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897171",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2808|Neuroinflammation and Neurodegeneration Mechanisms"
    ]
  ],
  "openalex": "W7213545083",
  "pdf_url": "https://europepmc.org/articles/PMC13680361?pdf=render",
  "pmcid": "PMC13680361",
  "pmid": "42897171",
  "published": "2026-09-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eczwgrjkn6zh9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897171",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897171"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neuroinflammation and Neurodegeneration Mechanisms",
      "subfield": "neurology"
    }
  ],
  "title": "Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice.",
  "title_text": "Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/eczwgrjkn6zh9",
  "venue": "Nature communications",
  "versions": []
}