{
  "abstract": "Over the past two decades, increasing attention has been devoted to regulated forms of cell death that occur independently of apoptosis. Among these, necroptosis and ferroptosis exhibit a necrotic-like morphology, yet are defined by distinct molecular and biochemical signatures. Both pathways have attracted considerable interest due to growing evidence implicating them in the pathogenesis of a wide range of acute and chronic disorders. Notably, the simultaneous engagement of multiple regulated necrosis pathways has been reported in many disease contexts, highlighting the limitations of single-target therapeutic approaches. In this light, the design of multi-target-directed ligands, that is, embracing a polypharmacological strategy, has emerged as a promising direction for the development of future therapies. In this review, we propose the concept of NecroFerrins, a class of small molecules that simultaneously inhibit necroptosis and ferroptosis. Within this class, we identify RIPROStatins as a distinct subclass of RIPK1 inhibitors that additionally possess radical-trapping antioxidant activity. The objective of this review is also to stimulate translational research on complex diseases using polypharmacological drugs acting as necrosis inhibitors.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Claire Delehouzé"
    },
    {
      "name": "Stéphane Bach"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ed2wn0ggs167k.bib",
  "cited_by": 0,
  "doi": "10.70401/fos.2026.0041",
  "fulltext_url": null,
  "id": "ed2wn0ggs167k",
  "issns": [
    "3106-8626",
    "3106-8626"
  ],
  "landing_url": "https://hal.science/hal-05783170v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Cell death mechanisms and regulation"
    ]
  ],
  "openalex": "W7203497296",
  "pdf_url": "https://hal.science/hal-05783170/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ed2wn0ggs167k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "hal-05783170",
      "source": "hal",
      "url": "https://hal.science/hal-05783170v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Cell death mechanisms and regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "NecroFerrins as dual therapeutic inhibitors targeting necroptosis and ferroptosis",
  "title_text": "NecroFerrins as dual therapeutic inhibitors targeting necroptosis and ferroptosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:50Z",
  "url": "https://research.draconitic.com/paper/ed2wn0ggs167k",
  "venue": "Ferroptosis and Oxidative Stress",
  "versions": []
}