{
  "abstract": "Embryonic stem cells are self-renewing, pluripotent cells, normally maintained by several pluripotency transcription factors. To respond to diverse differentiation and stress signaling pathways, the undifferentiated cell state must be destabilized before embryonic stem cells can properly interpret external signals to decide the cell fate. It remains incompletely understood how diverse signals promote the exit of the self-renewal state. Here, we show that both acute DNA damage and diverse differentiation signaling pathways converge at the proteasomal destruction of Estrogen-related receptor β (ESRRB), a key pluripotency transcription factor. Environmental agents such as UV light and genotoxic chemicals activate P-TEFb protein kinase to directly phosphorylate ESRRB to promote its proteasomal degradation. On the other hand, diverse differentiation signaling pathways also promote ESRRB degradation. Interestingly, the responsible kinase is GSK3β, instead of P-TEFb, in these biological contexts. Substituting five Ser residues in ESRRB with Ala confers resistance to GSK3β-dependent ESRRB degradation and compromises cell differentiation. These results demonstrate that conserved post-translational modifications in ESRRB integrate diverse signaling pathways to govern the fate of embryonic stem cells.",
  "abstract_shown": true,
  "affiliations": [
    "Departments of Laboratory Medicine, Obstetrics & Gynecology and Pediatrics, Cancer Center, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China",
    "Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China",
    "Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Haojie Duan"
    },
    {
      "affs": [
        1
      ],
      "name": "Qian Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuping Suo"
    },
    {
      "affs": [
        2
      ],
      "name": "Jin-An Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaojuan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yin Fang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ee5qsgpgg7fre.bib",
  "cited_by": 0,
  "doi": "10.3389/fcell.2026.1919736",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696285/",
  "id": "ee5qsgpgg7fre",
  "issns": [
    "2296-634X"
  ],
  "landing_url": "https://doi.org/10.3389/fcell.2026.1919736",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "1312|Pluripotent Stem Cells Research"
    ]
  ],
  "openalex": "W7221466813",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13696285/pdf/?tool=EBI",
  "pmcid": "PMC13696285",
  "pmid": "42935740",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ee5qsgpgg7fre.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:40Z",
      "native_id": "PMC13696285",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcell.2026.1919736"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13696285",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13696285"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Pluripotent Stem Cells Research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Conserved phosphorylation events in ESRRB integrate diverse signaling pathways to govern the fate of embryonic stem cells",
  "title_text": "Conserved phosphorylation events in ESRRB integrate diverse signaling pathways to govern the fate of embryonic stem cells",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:39Z",
  "url": "https://research.draconitic.com/paper/ee5qsgpgg7fre",
  "venue": "Frontiers in Cell and Developmental Biology",
  "versions": []
}