{
  "abstract": "The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, zebrafish and nematode. Applying massive feature extraction, we characterize local neural dynamics across >6,000 time-series features. This reveals a conserved dynamical profile of anesthesia across species, characterized by shorter intrinsic timescales of neural activity and dampened inter-regional synchrony. Deep-brain stimulation of the macaque centromedian thalamus reverses this profile and restores behavioral responsiveness. This conserved dynamical phenotype covaries with conserved transcriptional profiles of excitatory and inhibitory neurotransmission. Biophysical modeling provides a potential mechanistic link between the macroscale dynamical phenotype of anesthesia and microscale effects of key molecular targets on the timescales of synaptic excitation and inhibition. These analyses reveal a shared neural endpoint of anesthesia: across species and scales, anesthetics induce spatiotemporal isolation of local neural activity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry and Centre for Eudaimonia and Human Flourishing, University of Oxford, Oxford, UK. andrea.luppi@psych.ox.ac.uk",
    "Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada. andrea.luppi@psych.ox.ac.uk",
    "St John's College, University of Cambridge, Cambridge, UK. andrea.luppi@psych.ox.ac.uk",
    "Cognitive Neuroimaging Unit, CEA, INSERM, Université Paris-Saclay, NeuroSpin Center, Gif-sur-Yvette, France",
    "Department of Anesthesiology and Critical Care, Necker Hospital, Université de Paris Cité, Paris, France",
    "Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA",
    "Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA",
    "Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada",
    "Centre de recherche CERVO, Quebec City, Quebec, Canada",
    "Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan",
    "Laboratory for Marmoset Models of Brain Diseases, RIKEN Center for Brain Science, Wako, Japan",
    "Keio University Regenerative Medicine Research Center, Kawasaki, Japan",
    "Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany",
    "Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany",
    "Department of Anesthesiology and Intensive Care, Technical University of Munich, Munich, Germany",
    "Department of Neurology, Asklepios Clinic, Bad Tolz, Germany",
    "Department of Anaesthesiology and Intensive Care Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany",
    "University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland",
    "Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy",
    "Centre for Mind/Brain Sciences, University of Trento, Trento, Italy",
    "Department of Radiology, University of Calgary, Calgary, Alberta, Canada",
    "Paris-Saclay University, CNRS, Paris-Saclay Institute for Neuroscience (NeuroPSI), Saclay, France",
    "Center for Philosophy of Artificial Intelligence, University of Copenhagen, Copenhagen, Denmark",
    "Inria Centre, Université Côte d'Azur Nice, Valbonne, France",
    "Division of Anaesthesia, University of Cambridge, Cambridge, UK",
    "Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK",
    "Université Laval, Quebec City, Quebec, Canada",
    "Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA",
    "Department of Biomedical Engineering, Physiology and Biophysics, Boston University, Boston, MA, USA",
    "School of Physics, The University of Sydney, Sydney, New South Wales, Australia",
    "Cognitive Neuroimaging Unit, CEA, INSERM, Université Paris-Saclay, NeuroSpin Center, Gif-sur-Yvette, France. bechir.jarraya@gmail.com",
    "Department of Neurology, Foch Hospital, Suresnes, France. bechir.jarraya@gmail.com",
    "Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada. bratislav.misic@mcgill.ca"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 28,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Andrea I. Luppi",
      "orcid": "0000-0002-3461-6431"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Lynn Uhrig",
      "orcid": "0000-0002-2737-0197"
    },
    {
      "affs": [
        5,
        3
      ],
      "name": "Jordy Tasserie",
      "orcid": "0000-0001-9626-7823"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Golia Shafiei",
      "orcid": "0000-0002-2036-5571"
    },
    {
      "affs": [
        8
      ],
      "name": "Antoine Légaré",
      "orcid": "0009-0009-5414-9111"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Kanako Muta",
      "orcid": "0000-0002-6424-1538"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Junichi Hata",
      "orcid": "0000-0001-5833-444X"
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    {
      "affs": [
        11,
        10
      ],
      "name": "Hideyuki Okano",
      "orcid": "0000-0001-7482-5935"
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    {
      "affs": [
        12,
        13
      ],
      "name": "Daniel Golkowski",
      "orcid": "0000-0002-7569-7936"
    },
    {
      "affs": [
        14
      ],
      "name": "Andreas Ranft",
      "orcid": "0000-0002-0530-0796"
    },
    {
      "affs": [
        15,
        12
      ],
      "name": "Rüdiger Ilg"
    },
    {
      "affs": [
        16,
        17
      ],
      "name": "Denis Jordan",
      "orcid": "0000-0003-0743-9983"
    },
    {
      "affs": [
        18,
        19
      ],
      "name": "Silvia Gini",
      "orcid": "0009-0001-2757-3306"
    },
    {
      "affs": [
        7
      ],
      "name": "Zhen-Qi Liu",
      "orcid": "0000-0003-0917-7905"
    },
    {
      "affs": [
        20,
        7
      ],
      "name": "Yohan Yee",
      "orcid": "0000-0001-7083-1932"
    },
    {
      "affs": [
        3,
        21
      ],
      "name": "Pablo Castro",
      "orcid": "0009-0005-7262-0916"
    },
    {
      "affs": [
        22,
        3
      ],
      "name": "Camilo Miguel Signorelli",
      "orcid": "0000-0002-2110-7646"
    },
    {
      "affs": [
        23,
        21
      ],
      "name": "Rodrigo Cofré",
      "orcid": "0000-0002-7498-7122"
    },
    {
      "affs": [
        21
      ],
      "name": "Alain Destexhe A",
      "orcid": "0000-0001-7405-0455"
    },
    {
      "affs": [
        24
      ],
      "name": "David Krishna Menon",
      "orcid": "0000-0002-3228-9692"
    },
    {
      "affs": [
        25,
        24
      ],
      "name": "Emmanuel Andreas Stamatakis",
      "orcid": "0000-0001-6955-9601"
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    {
      "affs": [
        26
      ],
      "name": "Patrick Desrosiers",
      "orcid": "0000-0001-7528-697X"
    },
    {
      "affs": [
        26
      ],
      "name": "Paul De Koninck",
      "orcid": "0000-0002-6436-1062"
    },
    {
      "affs": [
        27,
        28
      ],
      "name": "Christopher W. Connor",
      "orcid": "0000-0003-1735-641X"
    },
    {
      "affs": [
        18
      ],
      "name": "Alessandro Gozzi",
      "orcid": "0000-0002-5731-4137"
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        29
      ],
      "name": "Ben Fulcher",
      "orcid": "0000-0002-3003-4055"
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    {
      "affs": [
        30,
        31
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      "name": "Béchir Jarraya",
      "orcid": "0000-0003-0878-763X"
    },
    {
      "affs": [
        32
      ],
      "name": "Bratislav Mišić",
      "orcid": "0000-0003-0307-2862"
    }
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  "bibtex": "https://research.draconitic.com/paper/eegg0n9ksd9y1.bib",
  "cited_by": 6,
  "doi": "10.1038/s41593-026-02460-4",
  "fulltext_url": null,
  "id": "eegg0n9ksd9y1",
  "issns": [
    "1097-6256",
    "1546-1726"
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  "landing_url": "https://inria.hal.science/hal-05769145v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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  "pdf_url": "https://www.nature.com/articles/s41593-026-02460-4.pdf",
  "pmcid": "PMC11974681",
  "pmid": "42811119",
  "published": "2026-09-29",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/eegg0n9ksd9y1.ris",
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  "subjects": [
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      "subfield": "neuroscience"
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  "title": "Comprehensive profiling of brain dynamics during anesthesia across phylogeny",
  "title_text": "Comprehensive profiling of brain dynamics during anesthesia across phylogeny",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:14Z",
  "url": "https://research.draconitic.com/paper/eegg0n9ksd9y1",
  "venue": "Nature Neuroscience",
  "versions": []
}