{
  "abstract": "The Pediatric Glittre Activities of Daily Living Test (TGlittre-P) is a field test designed to assess the functional performance of activities of daily living (ADL) in pediatric patients with cystic fibrosis (CF). However, the effects of TGlittre-P on heart rate response and the clinical determinants of test performance in this population remain insufficiently understood. To compare the heart rate response elicited by the TGlittre-P and the six-minute walk test (6MWT), and to identify pulmonary and extrapulmonary factors associated with TGlittre-P performance in pediatric patients with CF. Fifty-four pediatric patients with CF (mean age = 14.46 ± 2.16 years, 31 females and 23 males) were included in this cross-sectional study. ADL performance was assessed using the TGlittre-P, and functional capacity was assessed using the 6MWT. Pulmonary function, including forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC), maximal inspiratory and expiratory pressure (MIP and MEP, respectively), handgrip strength (HGS %) and quadriceps muscle strength (QMS %) were measured. A multiple linear regression analysis model was used to determine independent predictors of TGlittre-P performance. The mean TGlittre-P duration was 2.00 ± 0.53 min. There was agreement between recorded peak heart rate (HRpeak) responses during the TGlittre-P and 6MWT (mean difference: -2.33%, with limits of agreement ranging from − 41.19 to 36.52). HRpeak (bpm), HRpeak (% predicted HRmax), and pre-to-post changes in systolic and diastolic blood pressure (mmHg), oxygen saturation (%), and perceived effort were not different between TGlittre-P and 6MWT (p > 0.05). TGlittre-P duration (min) correlated with 6MWT distance (m), FEV1 (%), FEV1z-score, FVC (%), FVC z-score, MIP (cmH2O), MEP (cmH2O), HGS (%) and QMS (%) (p < 0.05). The FEV1 z-score, height z-score and sex were predictors for TGlittre-P duration (min) [Adjusted R2 = 0.402, F(3, 53) = 11.755, p < 0.001, constant = 1.625]. No significant differences were observed in the measured heart rate response between the TGlittre-P and 6MWT. TGlittre-P performance is strongly associated with pulmonary function and respiratory and peripheral muscle strength. Airway obstruction was the strongest predictor of TGlittre-P performance in this population.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Cemile Bozdemir",
      "orcid": "0000-0001-7375-2519"
    },
    {
      "name": "Elif Kocaaga",
      "orcid": "0000-0002-5650-8992"
    },
    {
      "name": "Haluk Tekerlek",
      "orcid": "0000-0003-4514-4801"
    },
    {
      "name": "Deniz Inal-Ince",
      "orcid": "0000-0002-8151-0664"
    },
    {
      "name": "Hulya Arikan",
      "orcid": "0000-0002-0028-4256"
    },
    {
      "name": "Melda Saglam",
      "orcid": "0000-0001-5323-1943"
    },
    {
      "name": "Naciye Vardar-Yagli",
      "orcid": "0000-0003-0218-140X"
    },
    {
      "name": "Ebru Calik",
      "orcid": "0000-0001-5215-5125"
    },
    {
      "name": "Ugur Ozcelik",
      "orcid": "0000-0003-1587-5216"
    },
    {
      "name": "Deniz Dogru",
      "orcid": "0000-0001-9931-9473"
    },
    {
      "name": "Nural Kiper",
      "orcid": "0000-0003-1261-7393"
    },
    {
      "name": "Ebru Gunes Yalcin",
      "orcid": "0000-0002-7325-1981"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eeqfymywrmnkz.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-74157-4",
  "fulltext_url": null,
  "id": "eeqfymywrmnkz",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-74157-4",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Cystic Fibrosis Research Advances"
    ]
  ],
  "openalex": "W7216338382",
  "pdf_url": "https://www.nature.com/articles/s41598-026-74157-4.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/eeqfymywrmnkz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.1038/s41598-026-74157-4",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-74157-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Cystic Fibrosis Research Advances",
      "subfield": "general"
    }
  ],
  "title": "Heart rate response and clinical determinants of Glittre activities of daily living test performance in pediatrics with cystic fibrosis",
  "title_text": "Heart rate response and clinical determinants of Glittre activities of daily living test performance in pediatrics with cystic fibrosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/eeqfymywrmnkz",
  "venue": "Scientific Reports",
  "versions": []
}