{
  "abstract": "Neurodegenerative diseases (NDDs) are increasingly recognized as systemic disorders shaped by the microbiota-gut-brain axis. Within this framework, gut microbiome dysbiosis is better defined by reproducible modules of functional imbalance than by isolated taxonomic shifts. These aberrant microbial networks transmit peripheral signals to the central nervous system through three interconnected routes: immune-inflammatory activation, metabolic reprogramming, and aberrant vagal and humoral neural transmission. Because peripheral inputs may converge on shared downstream pathways within the brain, they can drive mitochondrial decompensation, oxidative stress, and pathological protein aggregation. This review integrates current evidence into a conceptual framework describing how host-microbiome interactions may contribute to neurodegeneration and then critically appraises microbiome-targeted interventions, including dietary modulation, next-generation probiotics, and fecal microbiota transplantation. Moving from correlation-based reasoning toward a causal, mechanism-driven account, we argue for patient stratification and outline a path toward precision microecological therapies against NDDs.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University",
    "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine",
    "Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine",
    "Department of Laboratory Medicine, Lishui Second People’s Hospital",
    "Lishui Key Laboratory of Brain Health and Severe Brain Disorders, Department of Rehabilitation, Lishui Second People’s Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yangtian Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Yiwen Cheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Shengyu Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Xia Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaocui Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Pingping Hu"
    },
    {
      "affs": [
        3
      ],
      "name": "Lingbin Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Zongxin Ling"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongtao Gao"
    },
    {
      "affs": [
        4
      ],
      "name": "Guangyong Cai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eezqxqj5gehk2.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1969319",
  "fulltext_url": null,
  "id": "eezqxqj5gehk2",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1969319/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/eezqxqj5gehk2.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:33Z",
      "native_id": "10.3389/fimmu.2026.1969319",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1969319/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Gut microbiome dysbiosis as a convergent contributor of neurodegenerative disease: unifying mechanistic pathways and emerging precision microbiome-directed therapies",
  "title_text": "Gut microbiome dysbiosis as a convergent contributor of neurodegenerative disease: unifying mechanistic pathways and emerging precision microbiome-directed therapies",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:33Z",
  "url": "https://research.draconitic.com/paper/eezqxqj5gehk2",
  "venue": "Frontiers in Immunology",
  "versions": []
}