{
  "abstract": "Neoadjuvant regimens often fail to eliminate micrometastases due to profound immunosuppression and the limited immunogenicity of residual tumor cells. In this work, a versatile lipid nanoplatform was engineered to orchestrate potent chemotherapy with in situ neoantigen vaccination. Unlike conventional physical encapsulation, an arginine-modified SN38 prodrug (SN38-Arg) was synthesized to enhance amphiphilicity and facilitate the co-assembly with PEGylated lipids and tumor-specific peptides (HPV16 E7 or Adpgk). This design yields uniform ~115 nm nanomicelles with exceptional stability and > 60% peptide encapsulation efficiency. Mechanistically, these nanomicelles leverage folate-receptor targeting to achieve dual synchronization: SN38-Arg induces Topoisomerase I inhibition and extensive DNA damage, while simultaneously promoting dendritic cell maturation and antigen cross-presentation. In neoadjuvant murine models of HPV+ TC-1 and MSI-high MC38 tumors, a brief preoperative course of SFE/SFA not only significantly debulked primary tumors but, critically, prevented postsurgical recurrence of treated cohorts and established long-term protective memory T cell reservoirs. This was accompanied by a remodeled tumor immune microenvironment marked by elevated CD8⁺ T cell infiltration and the reduction of regulatory T cells and MDSCs, all without discernible systemic toxicity. This work establishes a clinically translatable, off-the-shelf nanomicellar strategy that integrates SN38-based chemotherapy with peptide vaccination, offering a compelling avenue to improve pathological complete response rates and long-term disease-free survival in surgical oncology.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.",
    "Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, School of Biomedical Sciences, Hunan University, Changsha, Hunan, 410082, China.",
    "Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China.",
    "State Key Laboratory of Respiratory Diseases, Guangzhou, 511436, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiaxin Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Miaoyan Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Ping Wan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Dexu Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueheng Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiyi Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaowei Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chengzhi Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Deng",
      "orcid": "0000-0002-1007-3794"
    },
    {
      "affs": [
        2
      ],
      "name": "Jialong Qi"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Wenjie Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ef8g5gkz1mrqf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijpx.2026.100681",
  "fulltext_url": "https://europepmc.org/articles/PMC13693331",
  "id": "ef8g5gkz1mrqf",
  "issns": [
    "2590-1567"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921442",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7221090540",
  "pdf_url": "https://europepmc.org/articles/PMC13693331?pdf=render",
  "pmcid": "PMC13693331",
  "pmid": "42921442",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ef8g5gkz1mrqf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42921442",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921442"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "The lipid nanomicelles incorporating peptide vaccine and SN38 prodrug potentiate neoadjuvant chemo-immunotherapy.",
  "title_text": "The lipid nanomicelles incorporating peptide vaccine and SN38 prodrug potentiate neoadjuvant chemo-immunotherapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/ef8g5gkz1mrqf",
  "venue": "International journal of pharmaceutics: X",
  "versions": []
}