{
  "abstract": "In this study, we report a novel function of protein phosphatase 1 regulatory subunit 3C (PPP1R3C)—which is known to promote glycogenesis by activating glycogen synthase and to inhibit glycogen breakdown by suppressing glycogen phosphorylase—as a tumor suppressor in endometrial cancer. First, the expression of PPP1R3C was strongly down-regulated in uterine corpus endometrial cancer (UCEC) tissues, and ectopic expression of PPP1R3C led to cell cycle arrest and apoptosis in HEC1A and HEC1B cells derived from UCEC. PPP1R3C also inhibited the growth of xenograft tumors in BALB/c nude mice. We found evidence indicating that the activation of glycogen synthesis was at least partly responsible for the tumor suppressor activity of PPP1R3C. Specifically, inhibition of glycogen synthase abrogated the effect of ectopic PPP1R3C expression on the growth inhibition of UCEC cells. Collectively, our data indicate that PPP1R3C is a tumor suppressor gene functioning through the induction of glycogen synthesis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Life Science, Ewha Womans University, Seoul 03760, Institute of Women",
    "Ewha Research Center for Systems Biology, Ewha Womans University, Seoul 03760, Institute of Women",
    "Department of Obstetrics and Gynecology, Institute of Women"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Hyang Sook Seol"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jaewon Kim"
    },
    {
      "affs": [
        2
      ],
      "name": "Ju Hee Oh"
    },
    {
      "affs": [
        2
      ],
      "name": "Eunhye Choi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sanghyuk Lee"
    },
    {
      "affs": [
        2
      ],
      "name": "Eun Ji Nam"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jaesang Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/efgghd4h63k10.bib",
  "cited_by": 0,
  "doi": "10.5483/bmbrep.2025-0134",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720689/",
  "id": "efgghd4h63k10",
  "issns": [
    "1976-6696",
    "1976-670X"
  ],
  "landing_url": "https://doi.org/10.5483/bmbrep.2025-0134",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2745|Glycogen Storage Diseases and Myoclonus"
    ]
  ],
  "openalex": "W7134016294",
  "pdf_url": "https://www.bmbreports.org/journal/download_pdf.php?doi=10.5483/BMBRep.2025-0134",
  "pmcid": "PMC13720689",
  "pmid": "41781186",
  "published": "2026-10-31",
  "publisher": "Korean Society for Biochemistry and Molecular Biology",
  "ris": "https://research.draconitic.com/paper/efgghd4h63k10.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:31Z",
      "native_id": "PMC13720689",
      "source": "pmc",
      "url": "https://doi.org/10.5483/bmbrep.2025-0134"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Genomics and Chromatin Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "PPP1R3C functions as a tumor suppressor in endometrial cancer through promotion of glycogen synthesis",
  "title_text": "PPP1R3C functions as a tumor suppressor in endometrial cancer through promotion of glycogen synthesis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:31Z",
  "url": "https://research.draconitic.com/paper/efgghd4h63k10",
  "venue": "BMB Reports",
  "versions": []
}