{
  "abstract": "Introduction\n\nUrobiome dysbiosis has been implicated in the pathogenesis of overactive bladder (OAB). In this study, the efficacy of a cranberry supplement for OAB symptoms was investigated, and concurrent urobiome alterations were evaluated in young women.Methods\n\nThis double-blind, randomized, placebo-controlled trial enrolled 26 women (median age, 23 years) with OAB (Overactive Bladder Symptom Score [OABSS] ≥ 3), who received either a cranberry supplement (36 mg proanthocyanidins per day) or placebo for 4 weeks. Clinical efficacy was assessed using the OABSS reduction rate, and urobiome composition was evaluated by 16S rRNA gene sequencing.Results\n\nTwenty-five participants were included in the analysis. At 4 weeks, the OABSS reduction rate was greater in the cranberry group than in the placebo group (median, 66.7% vs. 40.0%; p = 0.039). At baseline, the urobiome was dominated by Lactobacillus (median relative abundance, 64.2%). After cranberry supplementation, the relative abundance of Lactobacillus decreased within the cranberry group (median change, -4.39%; p = 0.027; q = 0.096). No compositional changes were observed in the placebo group.Conclusions\n\nCranberry supplementation was associated with greater improvement in OAB symptoms than was observed with placebo in young women, while a decrease in Lactobacillus relative abundance was observed within the cranberry group. Given the small sample size of this exploratory pilot trial and the limited species-level resolution of 16S rRNA sequencing, these concurrent findings should be regarded as hypothesis-generating and warrant further investigation.Clinical trial registration\n\nhttps://www.umin.ac.jp/ctr/, identifier UMIN000057544.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan.",
    "Clinical Training Center, Kansai Medical University, Hirakata, Osaka, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ayaka Ito"
    },
    {
      "affs": [
        0
      ],
      "name": "Shohei Akagawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuko Akagawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Shoji Tsuji"
    },
    {
      "affs": [
        0
      ],
      "name": "Shogo Kato"
    },
    {
      "affs": [
        0
      ],
      "name": "Sohsaku Yamanouchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Kazunari Kaneko"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/efkjwgqnp06at.bib",
  "cited_by": 0,
  "doi": "10.3389/fcimb.2026.1952206",
  "fulltext_url": "https://europepmc.org/articles/PMC13683685",
  "id": "efkjwgqnp06at",
  "issns": [
    "2235-2988"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908981",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2748|Urinary Bladder and Prostate Research"
    ]
  ],
  "openalex": "W7220831254",
  "pdf_url": "https://europepmc.org/articles/PMC13683685?pdf=render",
  "pmcid": "PMC13683685",
  "pmid": "42908981",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/efkjwgqnp06at.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42908981",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908981"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Urinary Bladder and Prostate Research",
      "subfield": "general"
    }
  ],
  "title": "Efficacy of a standardized cranberry supplement on overactive bladder symptoms and urobiome alterations in young women: a randomized, double-blind, placebo-controlled pilot trial.",
  "title_text": "Efficacy of a standardized cranberry supplement on overactive bladder symptoms and urobiome alterations in young women: a randomized, double-blind, placebo-controlled pilot trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/efkjwgqnp06at",
  "venue": "Frontiers in cellular and infection microbiology",
  "versions": []
}