{
  "abstract": "High-resolution chromosome imaging plays a key role in understanding chromosome structure. However, traditional methods for super-resolution (<200 nm) chromosome imaging are often complex and time-consuming, requiring purification, staining or sectioning of chromosomes. Here, we propose a novel and simple method to achieve correlative super-resolution imaging for label-free chromosomes through the utilization of the coffee-ring effect. An application of this method is shown to identify dicentric chromosomes and acentric fragments.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Modern Physics, Chinese Academy of Sciences , Lanzhou, People's Republic of China.",
    "Singapore Nuclear Research and Safety Institute, National University of Singapore , Singapore.",
    "Centre for Ion Beam Applications, Department of Physics, National University of Singapore , Singapore."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yanxin Dou",
      "orcid": "0000-0002-9183-9164"
    },
    {
      "affs": [
        1
      ],
      "name": "Valerie S T Goh",
      "orcid": "0000-0002-0016-609X"
    },
    {
      "affs": [
        2
      ],
      "name": "Thomas Osipowicz"
    },
    {
      "affs": [
        1
      ],
      "name": "Christelle E L Chua"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eg2862eav84j9.bib",
  "cited_by": 0,
  "doi": "10.1098/rsif.2026.0072",
  "fulltext_url": "https://europepmc.org/articles/PMC13682569",
  "id": "eg2862eav84j9",
  "issns": [
    "1742-5689",
    "1742-5662"
  ],
  "landing_url": "https://europepmc.org/article/MED/42869462",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1304|Advanced Fluorescence Microscopy Techniques"
    ]
  ],
  "openalex": "W7221710406",
  "pdf_url": "https://europepmc.org/articles/PMC13682569?pdf=render",
  "pmcid": "PMC13682569",
  "pmid": "42869462",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eg2862eav84j9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42869462",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42869462"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1304|Advanced Fluorescence Microscopy Techniques",
      "subfield": "biophysics"
    }
  ],
  "title": "Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes.",
  "title_text": "Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/eg2862eav84j9",
  "venue": "Journal of the Royal Society, Interface",
  "versions": []
}