{
  "abstract": "The pathophysiology underlying Parkinson's disease (PD) speech impairments and its potential sex differences remain unclear. We investigated sex-specific alterations in speech and striato-cortical networks in 104 patients with early PD (68M/36F), and 44 healthy controls (23M/21F), using quantitative speech markers and multimodal neuroimaging. Speech features related to prosody, phonation, articulation, fluency, and rhythm, were extracted from voice recordings; striatal dopaminergic loss was quantified using DaT-SPECT, and functional connectivity between striatal and cortical language networks was analyzed with resting-state fMRI. Results showed that PD-related speech impairments were more pronounced in males. Functional connectivity was globally reduced in PD, but female patients exhibited higher caudate-cortical connectivity. In males, speech deficits were associated with both dopaminergic loss and connectivity disruption, whereas in females, only connectivity changes were involved. These findings revealed sex-specific pathophysiological mechanisms in early PD speech disorders, emphasizing the need for sex-stratified approaches in research and clinical practice.",
  "abstract_shown": true,
  "affiliations": [
    "Institut du Cerveau - ICM, Inserm, CNRS, Sorbonne University, Paris, France.",
    "Biological Sciences Department, Columbia University, New York, NY, USA.",
    "Department of Neurosciences, Imaging, and Clinical Sciences, Institute for Advanced Biomedical Technologies, 'G. D'Annunzio' University of Chieti-Pescara, Chieti, Italy.",
    "AP-HP, Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France.",
    "AP-HP, Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.",
    "AP-HP, Sleep disorders unit, Pitié-Salpêtrière Hospital, Paris, France.",
    "AP-HP, Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, Paris, France.",
    "CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, LIB, Sorbonne University, Paris, France.",
    "Laboratoire SAMOVAR, Télécom SudParis, Institut Polytechnique de Paris, Palaiseau, France.",
    "Electrical & Computer Engineering Department, PERFORM Centre, Concordia University, Montreal, QC, Canada.",
    "Institut du Cerveau - ICM, Inserm, CNRS, Sorbonne University, Paris, France. laetitia.jeancolas@icm-institute.org.",
    "Electrical & Computer Engineering Department, PERFORM Centre, Concordia University, Montreal, QC, Canada. laetitia.jeancolas@icm-institute.org."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Caitlin Paige Rogers"
    },
    {
      "affs": [
        0
      ],
      "name": "Sandy Mournet"
    },
    {
      "affs": [
        0
      ],
      "name": "Cécile Gallea"
    },
    {
      "affs": [
        2
      ],
      "name": "Emma Biondetti"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Graziella Mangone"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Sara Sambin"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Lydia Chougar"
    },
    {
      "affs": [
        3
      ],
      "name": "Nicolas Villain"
    },
    {
      "affs": [
        0
      ],
      "name": "Rahul Gaurav"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Isabelle Arnulf"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Marie-Odile Habert"
    },
    {
      "affs": [
        8
      ],
      "name": "Dijana Petrovska-Delacrétaz"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Jean-Christophe Corvol"
    },
    {
      "affs": [
        9
      ],
      "name": "Habib Benali"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Marie Vidailhet"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Stéphane Lehéricy"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Laetitia Jeancolas",
      "orcid": "0000-0001-9202-5165"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eg3p7r3ckr8qa.bib",
  "cited_by": 0,
  "doi": "10.1038/s41531-026-01509-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13669323",
  "id": "eg3p7r3ckr8qa",
  "issns": [
    "2373-8057"
  ],
  "landing_url": "https://europepmc.org/article/MED/42875444",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Voice and Speech Disorders"
    ]
  ],
  "openalex": "W7221558538",
  "pdf_url": "https://europepmc.org/articles/PMC13669323?pdf=render",
  "pmcid": "PMC13669323",
  "pmid": "42875444",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eg3p7r3ckr8qa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42875444",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875444"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Voice and Speech Disorders",
      "subfield": "physiology"
    }
  ],
  "title": "Striatal network dysfunction underlying speech impairment in early Parkinson's disease.",
  "title_text": "Striatal network dysfunction underlying speech impairment in early Parkinson's disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/eg3p7r3ckr8qa",
  "venue": "NPJ Parkinson's disease",
  "versions": []
}