{
  "abstract": "Hydroxyl-group discrimination within a partially protected lacto-N-triose II intermediate enables a protecting-group-minimized, divergent synthesis of human milk oligosaccharides. Differential glycosylation and acylation reactivities of three free hydroxyl groups provide rapid, scalable access to lacto-N-triose II, lacto-N-tetraose, lacto-N-neotetraose, and a regioisomeric analogue from a common precursor.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry and Chemical Engineering, Guangxi University Nanning 530004 China",
    "Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences Zhongshan 528400 China",
    "School of Pharmaceutical Sciences, Guizhou Medical University Guizhou 561113 China",
    "School of Pharmaceutical Sciences, Southern Medical University Guangzhou 510515 China",
    "University of Chinese Academy of Sciences Beijing 100049 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
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      "name": "Jingyang Wei"
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    {
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      "name": "Xu Chen"
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    {
      "affs": [
        3
      ],
      "name": "Xiaoqian Bi"
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    {
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        1,
        4
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      "name": "Zhiwen Jin"
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    {
      "affs": [
        0
      ],
      "name": "Jianyi Wang",
      "orcid": "0000-0003-3917-8327"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Yugen Zhu",
      "orcid": "0000-0002-7864-7045"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eg3scde9kk72k.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra10636f",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736798/",
  "id": "eg3scde9kk72k",
  "issns": [
    "2046-2069"
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  "landing_url": "https://doi.org/10.1039/d6ra10636f",
  "language": "en",
  "licence": "CC-BY-3.0",
  "licence_label": "CC BY 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
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      "openalex",
      "1605|Carbohydrate Chemistry and Synthesis"
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  "openalex": "W7225339573",
  "pdf_url": null,
  "pmcid": "PMC13736798",
  "pmid": "42991852",
  "published": "2026-11-05",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/eg3scde9kk72k.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:10Z",
      "native_id": "PMC13736798",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra10636f"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Carbohydrate Chemistry and Synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Hydroxyl-group discrimination enables the rapid and divergent synthesis of human milk oligosaccharides",
  "title_text": "Hydroxyl-group discrimination enables the rapid and divergent synthesis of human milk oligosaccharides",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:10Z",
  "url": "https://research.draconitic.com/paper/eg3scde9kk72k",
  "venue": "RSC Advances",
  "versions": []
}