{
  "abstract": "Postoperative dysphagia is common after esophagectomy for thoracic esophageal cancer, but its long-term mechanisms remain poorly understood. This prospective study evaluated longitudinal changes in swallowing function and pressure dynamics through 6 months postoperatively. Thirteen patients who underwent subtotal esophagectomy with gastric conduit reconstruction were assessed preoperatively and at 1, 3, and 6 months postoperatively using a videofluoroscopic swallowing study (VFSS), fiberoptic endoscopic evaluation of swallowing (FEES), and the Eating Assessment Tool-10 (EAT-10). High-resolution manometry (HRM) was performed preoperatively and at 6 months postoperatively. EAT-10 scores increased significantly at 1 and 3 months, while the median score remained above baseline at 6 months without reaching statistical significance. VFSS demonstrated significant reductions in laryngeal elevation distance (LED) and hyoid forward displacement at 6 months. HRM revealed a significant increase in upper esophageal sphincter integrated relaxation pressure (UES-IRP), whereas meso-hypopharyngeal contractile integral (MHPCI) was unchanged. LED was negatively correlated with UES-IRP. Additional analyses showed no significant relationships between EAT-10 and LED or UES-IRP. Exploratory regression analyses suggested an association between anastomotic stricture and higher 6 months EAT-10 scores. These findings indicate that objective biomechanical abnormalities may persist despite an unclear relationship with patient-reported symptoms, supporting multimodal assessment using subjective and objective measures.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Junki Ono",
      "orcid": "0009-0003-6879-3203"
    },
    {
      "name": "Hideaki Nishi"
    },
    {
      "name": "Mari Ikenaga"
    },
    {
      "name": "Shinichiro Kobayashi"
    },
    {
      "name": "Kengo Kanetaka"
    },
    {
      "name": "Noriaki Makimoto"
    },
    {
      "name": "Sumie Takashima"
    },
    {
      "name": "Ayaka Mori"
    },
    {
      "name": "Mayuko Nakamura"
    },
    {
      "name": "Yuki Morotomi"
    },
    {
      "name": "Kosuke Sawase"
    },
    {
      "name": "Shuntaro Soejima"
    },
    {
      "name": "Yoshihiko Kumai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/egpgy32xfqtwg.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-78065-5",
  "fulltext_url": null,
  "id": "egpgy32xfqtwg",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-78065-5",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/egpgy32xfqtwg.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T00:20:35Z",
      "native_id": "10.1038/s41598-026-78065-5",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-78065-5"
    }
  ],
  "subjects": [],
  "title": "Swallowing biomechanics and upper esophageal sphincter pressure remain altered after esophagectomy for thoracic esophageal cancer",
  "title_text": "Swallowing biomechanics and upper esophageal sphincter pressure remain altered after esophagectomy for thoracic esophageal cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:20:51Z",
  "url": "https://research.draconitic.com/paper/egpgy32xfqtwg",
  "venue": "Scientific Reports",
  "versions": []
}