{
  "abstract": "Background and Objectives: Metaplastic breast carcinoma (MBC) is a rare, predominantly triple-negative breast cancer subtype with aggressive clinical behaviour. This study compared the clinicopathological characteristics and survival outcomes of MBC with triple-negative invasive breast carcinoma (TN-IBC) and assessed the prognostic value of the neutrophil-to-lymphocyte ratio (NLR). Materials and Methods: Patients with stage I-III MBC or TN-IBC diagnosed between January 2003 and January 2024 were retrospectively reviewed. Among 35 patients with MBC and 103 with TN-IBC, 1:1 propensity score matching by age and TNM stage generated two groups of 35 patients. Disease-free survival (DFS) and overall survival (OS) were evaluated using Kaplan-Meier estimates and Cox proportional hazards models with robust sandwich variance clustered by matched pair. Results: All 70 matched patients had triple-negative disease. During a median follow-up of 7.7 years, recurrence occurred in 22.9% of patients with MBC and 17.1% of those with TN-IBC, while mortality rates were 25.7% and 8.6%, respectively. Five-year DFS rates were 73.9% and 85.2%, respectively; however, MBC was not significantly associated with DFS (HR = 1.70, 95% CI 0.67-4.30; p = 0.262). Five-year OS rates were 79.8% and 94.3%, respectively. Metaplastic histology was associated with a higher mortality hazard (HR = 3.53, 95% CI 1.01-12.41; p = 0.049). Median NLR was higher in MBC than in TN-IBC (2.31 vs. 1.85; p = 0.019). High NLR was associated with poorer OS in the overall matched cohort (HR = 3.36, 95% CI 1.07-10.57; p = 0.038), although NLR was not significantly associated with survival when analysed as a continuous variable or within the MBC subgroup. Conclusions: MBC was associated with inferior OS compared with TN-IBC after propensity score matching and pair-adjusted survival analysis, while DFS did not differ significantly. Elevated NLR was associated with poorer OS in the overall matched cohort but was not validated as an MBC-specific prognostic biomarker.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Oncology, Aydin Ataturk State Hospital, Aydin 09020, Türkiye.",
    "Medical Oncology, Ali Osman Sonmez Oncology Hospital, Bursa 16040, Türkiye.",
    "Medical Oncology, Bursa City Hospital, Bursa 16110, Türkiye.",
    "Radiation Oncology, Balikesir Ataturk City Hospital, Balikesir 10100, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Burcu Caner",
      "orcid": "0000-0003-1591-3323"
    },
    {
      "affs": [
        1
      ],
      "name": "Hulya Ertas",
      "orcid": "0000-0002-5872-8825"
    },
    {
      "affs": [
        2
      ],
      "name": "Sibel Oyucu Orhan",
      "orcid": "0000-0001-8217-3471"
    },
    {
      "affs": [
        3
      ],
      "name": "Seher Bahar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/egr66ntb63af3.bib",
  "cited_by": 0,
  "doi": "10.3390/medicina62101944",
  "fulltext_url": "https://europepmc.org/articles/PMC13707025",
  "id": "egr66ntb63af3",
  "issns": [
    "1010-660X",
    "1648-9144"
  ],
  "landing_url": "https://europepmc.org/article/MED/42942475",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Breast Cancer Treatment Studies"
    ]
  ],
  "openalex": "W7221028652",
  "pdf_url": "https://europepmc.org/articles/PMC13707025?pdf=render",
  "pmcid": "PMC13707025",
  "pmid": "42942475",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/egr66ntb63af3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42942475",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42942475"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Breast Cancer Treatment Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Survival Outcomes in Metaplastic Versus Triple-Negative Invasive Breast Carcinoma: A Propensity Score-Matched Study.",
  "title_text": "Survival Outcomes in Metaplastic Versus Triple-Negative Invasive Breast Carcinoma: A Propensity Score-Matched Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/egr66ntb63af3",
  "venue": "Medicina (Kaunas, Lithuania)",
  "versions": []
}