{
  "abstract": "Consumption of ultra-processed food is associated with increased caloric intake and impaired health. Here, we conducted a nutrition trial (NCT05368194) with controlled, 2 × 2 crossover design and tested whether ultra-processed food impairs reproductive and metabolic fitness, with further aggravation by excess caloric intake. Comparing the response from an unprocessed to ultra-processed diet identified increased body weight and low-density lipoprotein (LDL):high-density lipoprotein (HDL) ratio, independent of caloric load. Several hormones involved in energy metabolism and spermatogenesis were affected, including decreased levels of growth/differentiation factor 15 and follicle-stimulating hormone. Sperm quality trended toward impairment, with a decrease in total motility. Differential accumulation of pollutants between the discordant diets were detected, such as decreased plasma lithium and a trend for increased levels of the phthalate mono (4-methyl-7-carboxyheptyl)phthalate (cxMINP) in serum, following the ultra-processed diet. Alteration in caloric load alone had distinct effects on the measured outcomes. This study provides evidence that consumption of ultra-processed food is detrimental for cardiometabolic and reproductive outcomes, regardless of excessive caloric intake.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Jessica M Preston"
    },
    {
      "name": "Jo Iversen"
    },
    {
      "name": "Antonia Hufnagel"
    },
    {
      "name": "Line Hjort"
    },
    {
      "name": "Jodie Taylor"
    },
    {
      "name": "Clara Sanchez"
    },
    {
      "name": "Victoria George"
    },
    {
      "name": "Ann N Hansen"
    },
    {
      "name": "Lars Ängquist"
    },
    {
      "name": "Susan Hermann"
    },
    {
      "name": "Jeffrey M Craig"
    },
    {
      "name": "Signe Torekov"
    },
    {
      "name": "Christian Lindh"
    },
    {
      "name": "Karin S Hougaard"
    },
    {
      "name": "Marcelo A Nóbrega"
    },
    {
      "name": "Stephen J Simpson"
    },
    {
      "name": "Romain Barrès"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/egvj1pypbhehp.bib",
  "cited_by": 40,
  "doi": "10.1016/j.cmet.2025.08.004",
  "fulltext_url": null,
  "id": "egvj1pypbhehp",
  "issns": [
    "1550-4131"
  ],
  "landing_url": "https://hal.science/hal-05849815v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.aen"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "1.sdv.spee"
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    [
      "hal",
      "2.sdv.mhep.em"
    ],
    [
      "openalex",
      "2739|Consumer Attitudes and Food Labeling"
    ]
  ],
  "openalex": "W4413788820",
  "pdf_url": "https://hal.science/hal-05849815/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/egvj1pypbhehp.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:20:50Z",
      "native_id": "hal-05849815",
      "source": "hal",
      "url": "https://hal.science/hal-05849815v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.em",
      "subfield": "endocrinology-metabolism"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.aen",
      "subfield": "nutrition"
    }
  ],
  "title": "Effect of ultra-processed food consumption on male reproductive and metabolic health",
  "title_text": "Effect of ultra-processed food consumption on male reproductive and metabolic health",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:12Z",
  "url": "https://research.draconitic.com/paper/egvj1pypbhehp",
  "venue": "Cell Metabolism",
  "versions": []
}