{
  "abstract": "Introduction: The triglyceride-glucose–body mass index, which integrates the triglyceride-glucose index with body mass index, has emerged as a promising marker of metabolic risk for heart failure with preserved ejection fraction; however, its association with subclinical diastolic dysfunction remains underexplored.\n\nMethods: This cross-sectional study enrolled 1,467 participants from a Chinese community-based population who underwent echocardiographic evaluation and metabolic profiling. The triglyceride-glucose–body mass index was calculated as the natural logarithm of triglycerides multiplied by fasting blood glucose divided by 2, then multiplied by body mass index. Ultrasound-defined diastolic dysfunction was diagnosed according to the 2025 American Society of Echocardiography criteria. Multivariable logistic regression, restricted cubic spline analysis, and machine learning were employed to evaluate the association.\n\nResults: The prevalence of ultrasound-defined diastolic dysfunction was 33.6%. The optimal Youden-derived triglyceride-glucose–body mass index cutoff was 220.000, categorizing participants into low ( n = 543 ) and high ( n = 924 ) groups. In the fully adjusted model, each 1-standard deviation increase was not significantly associated with ultrasound-defined diastolic dysfunction in continuous analysis (odds ratio=1.35; 95% confidence interval: 0.42–4.40; P = 0.616 ); however, the binary comparison showed a significant association (odds ratio=1.60; 95% confidence interval: 1.11–2.31; P = 0.013 ). Restricted cubic spline analysis revealed a significant overall association ( P overall < 0.001 ) without significant nonlinearity ( P nonlinear = 0.194 ).\n\nDiscussion: In this cohort, the triglyceride-glucose–body mass index demonstrated a significant independent association with ultrasound-defined diastolic dysfunction in the binary analysis, supporting its potential as a screening index for subclinical diastolic dysfunction, although external validation in independent populations is needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University",
    "Cardiovascular Institute of Luohe, Luohe Central Hospital, Luohe Medical College"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pengcheng Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Jing Bai"
    },
    {
      "affs": [
        1
      ],
      "name": "Jirui Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingyi Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhiwei Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jin Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Bing He"
    },
    {
      "affs": [
        1
      ],
      "name": "Qiaotao Xie"
    },
    {
      "affs": [
        1
      ],
      "name": "Haoran Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/egybv6qwka2gh.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1952042",
  "fulltext_url": "https://europepmc.org/articles/PMC13686918",
  "id": "egybv6qwka2gh",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1952042/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "openalex",
      "2705|Cardiovascular Function and Risk Factors"
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  "openalex": "W7220913391",
  "pdf_url": "https://europepmc.org/articles/PMC13686918?pdf=render",
  "pmcid": "PMC13686918",
  "pmid": "42923079",
  "published": "2026-10-08",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/egybv6qwka2gh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.1952042",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1952042/full"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923079",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923079"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Function and Risk Factors",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Triglyceride-glucose–body mass index as an integrated marker for ultrasound-defined diastolic dysfunction: variable importance via machine learning and SHAP analysis in a Chinese community cohort",
  "title_text": "Triglyceride-glucose–body mass index as an integrated marker for ultrasound-defined diastolic dysfunction: variable importance via machine learning and SHAP analysis in a Chinese community cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/egybv6qwka2gh",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}