{
  "abstract": "Background\n\nEctopic Cushing's syndrome (ECS) is a rare cause of hypercortisolism resulting from non-pituitary adrenocorticotropic hormone (ACTH) secretion, most associated with neuroendocrine tumors (NETs) of pulmonary or gastrointestinal origin. Mediastinal NETs are an extremely rare source.Case presentation\n\nWe report the case of a 23-year-old male with no relevant medical history, presenting with progressive muscle weakness, hyperpigmentation, weight gain, and signs of severe hypercortisolism, including moon facies, ecchymosis, hypertension, hyperglycemia, and hypokalemia. Hormonal tests confirmed ECS with markedly elevated ACTH and cortisol levels. Imaging revealed two anterior mediastinal masses. Histopathological analysis of the surgical specimens confirmed ACTH-producing atypical NETs.Conclusions\n\nThis case highlights the importance of considering ectopic ACTH secretion from mediastinal neuroendocrine tumors in the differential diagnosis of severe, rapidly progressive hypercortisolism. Early recognition and timely surgical management can prevent life-threatening complications and improve patient outcomes, even in rare and aggressive presentations.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Endocrinology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.",
    "Universidad Peruana Cayetano Heredia, Lima, Peru.",
    "Division of Anatomic Pathology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.",
    "Grupo de Investigacion en Neurociencias, Metabolismo, Efectividad Clinicay Salud Publica, Universidad Científica del Sur, Lima, Peru.",
    "School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.",
    "Division of Research, Hospital de Apoyo Chepen, Chepen, Peru."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Edita Guadalupe Ruiz-Huaranga"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria Del Pilar Quinones Avila"
    },
    {
      "affs": [
        0
      ],
      "name": "Rosa Laurie Marcilla Truyenque"
    },
    {
      "affs": [
        3
      ],
      "name": "Marcio Jose Concepcion-Zavaleta"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Jose Paz-Ibarra"
    },
    {
      "affs": [
        3
      ],
      "name": "Jenyfer Fuentes-Mendoza"
    },
    {
      "affs": [
        5
      ],
      "name": "Juan Eduardo Quiroz-Aldave"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eh31f5vmzjr7f.bib",
  "cited_by": 0,
  "doi": "10.22088/cjim.17.3.681",
  "fulltext_url": "https://europepmc.org/articles/PMC13690170",
  "id": "eh31f5vmzjr7f",
  "issns": [
    "2008-6164",
    "2008-6172"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924379",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Neuroendocrine Tumor Research Advances"
    ]
  ],
  "openalex": "W7216934606",
  "pdf_url": "https://europepmc.org/articles/PMC13690170?pdf=render",
  "pmcid": "PMC13690170",
  "pmid": "42924379",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eh31f5vmzjr7f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42924379",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924379"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Neuroendocrine Tumor Research Advances",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "First case report of ectopic Cushing's syndrome secondary to synchronous mediastinal neuroendocrine tumors.",
  "title_text": "First case report of ectopic Cushing's syndrome secondary to synchronous mediastinal neuroendocrine tumors.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/eh31f5vmzjr7f",
  "venue": "Caspian journal of internal medicine",
  "versions": []
}