{
  "abstract": "A palladium-catalyzed strategy for the one-pot synthesis of quinolone derivatives from (hetero)arylamides and functionalized 1,2-dihalobenzenes is described. The transformation likely proceeds through a Pd 1,4-migration from the amide nitrogen atom to the (hetero)aryl ring or via a direct ortho-metalation process, enabling first the ortho-arylation of the (hetero)arylamide. The key C–C bond is formed via the direct functionalization of two distinct C–H bonds, avoiding the need for a prefunctionalized amide coupling partner. Subsequent intramolecular C–N bond formation via Pd-catalyzed coupling efficiently furnishes the quinolone scaffold. The protocol exhibits broad functional group tolerance, accommodating diverse substituents on the 1,2-dihalobenzene as well as a range of (hetero)aryl amides. This methodology allows the installation of functional groups at defined positions on the (hetero)aromatic rings. Additionally, the use of an air-stable, readily accessible palladium catalyst in combination with an inexpensive base enhances the synthetic utility of the process.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Bo Lan"
    },
    {
      "name": "Thierry Roisnel"
    },
    {
      "name": "Henri Doucet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eh96zd8fvnkm1.bib",
  "cited_by": 0,
  "doi": "10.1039/d6qo00563b",
  "fulltext_url": null,
  "id": "eh96zd8fvnkm1",
  "issns": [
    "2052-4110",
    "2052-4129"
  ],
  "landing_url": "https://hal.science/hal-05742141v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.orga"
    ],
    [
      "openalex",
      "1605|Catalytic C–H Functionalization Methods"
    ]
  ],
  "openalex": "W7164899544",
  "pdf_url": "https://hal.science/hal-05742141/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/eh96zd8fvnkm1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:48Z",
      "native_id": "hal-05742141",
      "source": "hal",
      "url": "https://hal.science/hal-05742141v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.orga",
      "subfield": "organic"
    }
  ],
  "title": "Palladium direct arylation and annulation for the catalyzed regiocontrolled synthesis of quinolone derivatives",
  "title_text": "Palladium direct arylation and annulation for the catalyzed regiocontrolled synthesis of quinolone derivatives",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:48Z",
  "url": "https://research.draconitic.com/paper/eh96zd8fvnkm1",
  "venue": "Organic Chemistry Frontiers",
  "versions": []
}