{
  "abstract": "A murine IgG2b monoclonal antibody, named TG11, binding to an extracellular polysaccharide antigen secreted by all Mucorales fungi has been recently developed and integrated into a lateral-flow device (TG11-LFD). The aim of this study was to establish the clinical performance of TG11-LFD on bronchoalveolar lavage (BAL) fluids for the diagnosis of mucormycosis. Thirteen BAL samples from 13 patients with mucormycosis, all of which tested positive for Mucorales qPCR ( Mucor/Rhizopus [ n = 5], Lichtheimia [ n = 2], Rhizomucor [ n = 5], and Cunninghamella [ n = 1]), were used to assess the TG11-LFD. We also selected 49 BAL samples from 25 patients with other invasive fungal infections (IFI) (aspergillosis, Pneumocystis infection, candidiasis, and possible IFI) and from 20 patients without IFI for use as negative controls. The intensities of the test and control lines were recorded using a Cube reader. The diagnostic performance was assessed by analyzing the receiver operating characteristics (ROC) curve with the Jamovi software package (version 2.6.13). The area under the curve of the ROC curve was 0.739. Using a threshold value positivity ≤531 artificial units, the TG11-LFD test has a sensitivity and specificity of 76.92% and 75.51%, respectively, a positive predictive value of 45.45%, and a negative predictive value of 92.5%. In this study, we evaluated the performance of TG11-LFD on clinical samples for the first time and demonstrated its significant potential for enhancing the rapid detection of mucormycosis. Combining antigen detection with qPCR, as successfully applied in the diagnosis of aspergillosis, is likely to yield the most reliable diagnostic approach..",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Julie Rousselot"
    },
    {
      "name": "Laurence Millon"
    },
    {
      "name": "Emeline Scherer"
    },
    {
      "name": "Nathalie Bourgeois"
    },
    {
      "name": "Sebastien Imbert"
    },
    {
      "name": "Damien Dupont"
    },
    {
      "name": "Anne Debourgogne"
    },
    {
      "name": "Danièle Maubon"
    },
    {
      "name": "Anne Pauline Bellanger"
    },
    {
      "name": "Christopher Thornton"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ehdg1tyywjj50.bib",
  "cited_by": 13,
  "doi": "10.1128/jcm.00226-25",
  "fulltext_url": null,
  "id": "ehdg1tyywjj50",
  "issns": [
    "0095-1137"
  ],
  "landing_url": "https://hal.science/hal-05757350v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ib"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "1.sdv.mp"
    ],
    [
      "hal",
      "2.sdv.mhep.mi"
    ],
    [
      "hal",
      "2.sdv.mhep.psr"
    ],
    [
      "hal",
      "2.sdv.mp.bac"
    ],
    [
      "openalex",
      "2725|Antifungal resistance and susceptibility"
    ]
  ],
  "openalex": "W4411418993",
  "pdf_url": "https://hal.science/hal-05757350/document",
  "pmcid": null,
  "pmid": "40530880",
  "published": "2026-09-21",
  "publisher": "American Society for Microbiology",
  "ris": "https://research.draconitic.com/paper/ehdg1tyywjj50.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:37Z",
      "native_id": "hal-05757350",
      "source": "hal",
      "url": "https://hal.science/hal-05757350v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.mp",
      "subfield": "microbiology"
    },
    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.mi",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device",
  "title_text": "Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/ehdg1tyywjj50",
  "venue": "Journal of Clinical Microbiology",
  "versions": []
}