{
  "abstract": "Fragile X Syndrome (FXS) is a common inherited monogenic cause of autism spectrum disorder and intellectual disability (ASD/ID), conditions frequently associated with altered sensory processing and multisensory integration. However, the circuit mechanisms underlying these alterations remain poorly understood. Here, we investigate the integration of visual and self-motion information in the head-direction (HD) system in a rat model of FXS (Fmr1-/y rats). Using high-density silicon probes, we recorded neuronal activity in the postsubiculum (PoSub), a cortical hub of the HD system, while adult Fmr1-/y and wild-type (WT) rats experienced repeated rotations of a visual landmark. In WT rats, the HD signal only partially followed landmark rotations, consistent with weighted integration of visual and self-motion information, and visual landmark control progressively weakened across repeated cue conflicts. In contrast, the HD signal in Fmr1-/y rats closely followed landmark rotations and failed to show experience-dependent recalibration. This enhanced visual capture was accompanied by reduced angular head velocity tuning in PoSub neurons, indicating weakened representation of self-motion information. Together, these findings reveal an altered balance between visual and self-motion inputs to the HD system in a rat model of FXS and identify a possible circuit-level mechanism through which sensory integration of vision and self-motion may be disrupted in ASD/ID.",
  "abstract_shown": true,
  "affiliations": [
    "The University of Manchester"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. J. Duszkiewicz"
    },
    {
      "name": "A. A. Rastedt"
    },
    {
      "name": "A. Vadher"
    },
    {
      "name": "E. R. Wood"
    },
    {
      "name": "A. Peyrache"
    },
    {
      "name": "P. A. Dudchenko"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ehs20sff6vwbn.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.06.764867",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764867v1.full",
  "id": "ehs20sff6vwbn",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764867v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764867v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ehs20sff6vwbn.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:24:16Z",
      "native_id": "10.64898/2026.11.06.764867",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764867v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Visual capture of the head-direction signal in a rat model of Fragile X Syndrome",
  "title_text": "Visual capture of the head-direction signal in a rat model of Fragile X Syndrome",
  "type": "preprint",
  "updated_at": "2026-11-10T00:24:16Z",
  "url": "https://research.draconitic.com/paper/ehs20sff6vwbn",
  "venue": "bioRxiv",
  "versions": []
}