{
  "abstract": "Background: Obstructive sleep apnoea (OSA) is characterised by intermittent hypoxaemia and systemic inflammation. Hypoxic burden has emerged as a physiologically relevant marker of disease severity, but its relationship with inflammatory biomarkers and respiratory muscle strength remains unclear.\n\nMethods: In this multicentre cross-sectional study, 137 adults with suspected OSA from tertiary care centres in Lahore, Pakistan underwent overnight attended polysomnography using standardised protocols. Hypoxic burden was quantified as the cumulative area under the oxygen desaturation curve across sleep. Fasting blood samples were analysed for C reactive protein (CRP), interleukin-6, tumour necrosis factor-alpha, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio using standard laboratory methods. Respiratory muscle strength was assessed using maximal inspiratory and expiratory pressures. Clinical, anthropometric and questionnaire-based data were also collected. Multivariable linear regression models were used to examine factors independently associated with hypoxic burden and systemic inflammation after adjustment for potential confounders.\n\nResults: OSA severity was associated with increases in age, body mass index (BMI), blood pressure, hypoxic burden and inflammatory biomarkers, alongside reductions in respiratory muscle strength (all p<0.05). Hypoxic burden demonstrated the strongest association with disease severity (η²=0.73, p=0.001). In multivariable analysis, higher BMI (β=1.35, p=0.002), older age (β=0.25, p=0.024), higher Epworth Sleepiness Scale score (β=0.50, p=0.015) and lower inspiratory muscle strength (β=−0.68, p=0.007) were independently associated with greater hypoxic burden (adjusted R²=0.47). Systemic inflammation (CRP) was independently associated with higher BMI (β=0.28, p=0.003), greater hypoxic burden (β=0.045, p=0.004) and lower inspiratory muscle strength (β=−0.10, p=0.009) (adjusted R²=0.58). Inflammatory markers increased progressively, while maximal inspiratory pressure and maximal expiratory pressure declined across OSA severity.\n\nConclusions: Hypoxic burden was independently associated with disease severity and systemic inflammation in OSA, while reduced respiratory muscle strength was independently associated with greater hypoxaemia and systemic inflammation.",
  "abstract_shown": true,
  "affiliations": [
    "University Institute of Physical Therapy, The University of Lahore, Lahore, Pakistan",
    "The University of Lahore, Lahore, Pakistan",
    "Department of Physical Education and Sports Science, Islamic Azad University Khorasgan Branch, Isfahan, Iran (the Islamic Republic of)"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arsalan Tariq",
      "orcid": "0009-0001-1606-280X"
    },
    {
      "affs": [
        1
      ],
      "name": "Abdul Saad"
    },
    {
      "affs": [
        2
      ],
      "name": "Sayed Alireza Mousavi Zadeh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ehxknzj7wf0ns.bib",
  "cited_by": 0,
  "doi": "10.1136/bmjresp-2026-004397",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13711620/",
  "id": "ehxknzj7wf0ns",
  "issns": [
    "2052-4439"
  ],
  "landing_url": "https://doi.org/10.1136/bmjresp-2026-004397",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "1506"
    ],
    [
      "heading",
      "2232"
    ],
    [
      "heading",
      "Original Research"
    ],
    [
      "heading",
      "Sleep"
    ],
    [
      "openalex",
      "2737|Obstructive Sleep Apnea Research"
    ]
  ],
  "openalex": "W7223663720",
  "pdf_url": "https://bmjopenrespres.bmj.com/content/13/1/e004397.full.pdf",
  "pmcid": "PMC13711620",
  "pmid": "42933813",
  "published": "2026-10-26",
  "publisher": "BMJ Publishing Group",
  "ris": "https://research.draconitic.com/paper/ehxknzj7wf0ns.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:22Z",
      "native_id": "PMC13711620",
      "source": "pmc",
      "url": "https://doi.org/10.1136/bmjresp-2026-004397"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Obstructive Sleep Apnea Research",
      "subfield": "physiology"
    }
  ],
  "title": "Hypoxic burden, systemic inflammation and respiratory muscle dysfunction in obstructive sleep apnoea: a multicentre cross-sectional study",
  "title_text": "Hypoxic burden, systemic inflammation and respiratory muscle dysfunction in obstructive sleep apnoea: a multicentre cross-sectional study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:22Z",
  "url": "https://research.draconitic.com/paper/ehxknzj7wf0ns",
  "venue": "BMJ Open Respiratory Research",
  "versions": []
}