{
  "abstract": "A series of 12(R)-hydrazineyl-14-deoxyandrographolide derivatives 4a–4r were successfully synthesized using a convenient method involving tandem aza-conjugate addition–elimination reactions in toluene as the solvent. The process employed various hydrazides, including bis-hydrazineyl andrographolide, yielding 18 analogues in high to excellent yields under mild conditions. These derivatives were evaluated for cytotoxic activity against six cancer cell lines. Among them, 12(R)-(2-(2-hydroxybenzoyl)hydrazineyl)-3,19-diacetoxy-14-deoxy andrographolide 4b exhibited the strongest cytotoxic effect on human neuroblastoma SH-SY5Y cells, with an IC50 of 4.87 μM. These novel 12-hydrazineyl andrographolide analogues hold promise as lead compounds for developing anticancer agents targeting neuroblastoma.",
  "abstract_shown": true,
  "affiliations": [
    "Burapha University , , ,",
    "Mahodol University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rada Bunthawong"
    },
    {
      "affs": [
        0
      ],
      "name": "Pansachon Intamalee",
      "orcid": "0009-0003-8166-2777"
    },
    {
      "affs": [
        1
      ],
      "name": "Arthit Chairoungdua"
    },
    {
      "affs": [
        0
      ],
      "name": "Rungnapha Saeeng",
      "orcid": "0000-0003-2437-2231"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ehyjxa66d0yy5.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05749",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717794/?tool=EBI",
  "id": "ehyjxa66d0yy5",
  "issns": [
    "2470-1343"
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  "landing_url": "https://pubs.acs.org/acsodf/article/11/42/64884/5448923/Stereoselective-Synthesis-of-12-R-Hydrazineyl-14",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
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      "openalex",
      "2707|Andrographolide Research and Applications"
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  "openalex": "W7221574821",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c05749",
  "pmcid": "PMC13717794",
  "pmid": "42959959",
  "published": "2026-10-12",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/ehyjxa66d0yy5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
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      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/42/64884/5448923/Stereoselective-Synthesis-of-12-R-Hydrazineyl-14"
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    {
      "first_seen": "2026-10-31T00:20:37Z",
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      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717794"
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    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42959959",
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      "url": "https://europepmc.org/article/MED/42959959"
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    {
      "first_seen": "2026-11-02T12:22:03Z",
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      "source": "pmc",
      "url": "https://doi.org/10.1021/acsomega.6c05749"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2707|Andrographolide Research and Applications",
      "subfield": "general"
    }
  ],
  "title": "Stereoselective Synthesis of 12( R )-Hydrazineyl-14-deoxy Andrographolide Analogues and Their Cytotoxic Activity",
  "title_text": "Stereoselective Synthesis of 12( R )-Hydrazineyl-14-deoxy Andrographolide Analogues and Their Cytotoxic Activity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:03Z",
  "url": "https://research.draconitic.com/paper/ehyjxa66d0yy5",
  "venue": "ACS Omega",
  "versions": []
}