{
  "abstract": "OBJECTIVE: To investigate whether omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation improve cognitive performance and if apolipoprotein E (APOE) genotype or age were effect modifiers. METHODS: Healthy adults of 20 to 80 years old (n = 193) were completed a 6-month double-blind randomized controlled trial with two groups: 2.5 g/day of n-3 PUFA or a placebo. Primary outcomes were visuospatial ability and working memory and secondary outcomes were episodic memory and executive function, measured at baseline and 6 months. RESULTS: Cognitive performances did not significantly differ between groups on primary or secondary outcomes after 6 months of treatment. APOE carriers and age were not effect modifiers for any outcomes. Those with low episodic memory scores and taking the n-3 PUFA supplement, significantly improved their scores (p = 0.043). CONCLUSIONS: A 6-month n-3 PUFA supplementation did not improve cognitive performance in cognitively healthy adults and APOE status or age were not effect modifiers.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Mathieu Maltais"
    },
    {
      "name": "Dominique Lorrain"
    },
    {
      "name": "Pauline Léveillé"
    },
    {
      "name": "Isabelle Viens"
    },
    {
      "name": "Annick Vachon"
    },
    {
      "name": "Anita Houeto"
    },
    {
      "name": "Nancy Presse"
    },
    {
      "name": "Mélanie Plourde"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ej10f6qkph067.bib",
  "cited_by": 23,
  "doi": "10.1016/j.plefa.2022.102415",
  "fulltext_url": null,
  "id": "ej10f6qkph067",
  "issns": [
    "0952-3278"
  ],
  "landing_url": "https://hal.science/hal-05790370v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2916|Fatty Acid Research and Health"
    ]
  ],
  "openalex": "W4220759182",
  "pdf_url": "http://www.plefa.com/article/S0952327822000278/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/ej10f6qkph067.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "hal-05790370",
      "source": "hal",
      "url": "https://hal.science/hal-05790370v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Long-chain Omega-3 fatty acids supplementation and cognitive performance throughout adulthood: A 6-month randomized controlled trial.",
  "title_text": "Long-chain Omega-3 fatty acids supplementation and cognitive performance throughout adulthood: A 6-month randomized controlled trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/ej10f6qkph067",
  "venue": "Prostaglandins, Leukotrienes and Essential Fatty Acids",
  "versions": []
}