{
  "abstract": "Set-based genetic association tests provide a powerful framework for detecting genetic effects on complex traits by jointly analyzing multiple genetic variants. Although set-based methods have been developed for interval-censored survival outcomes, existing approaches primarily focus on a single survival phenotype and therefore do not fully use information from multiple correlated outcomes. In this paper, we develop two Weighted V Tests for Multivariate Interval-Censored Data (WV-M-IC), extending the weighted V-statistic framework (Wu et al., 2021) to the joint analysis of multiple correlated interval-censored survival outcomes. The performance of these methods is evaluated through simulation studies, showing that the proposed approaches can provide power gains compared with single-outcome analyses. We apply the proposed methods to the ZOE 2.0 study to investigate dental caries progression in children.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2609.00456",
  "author_total": 6,
  "authors": [
    {
      "name": "Juhee Lee"
    },
    {
      "name": "Kun Xia"
    },
    {
      "name": "Jianrui Zhang"
    },
    {
      "name": "Gongjun Xu"
    },
    {
      "name": "Qing Lu"
    },
    {
      "name": "Chenxi Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ej4sc1s6a1hrb.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2609.00456",
  "fulltext_url": null,
  "id": "ej4sc1s6a1hrb",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2609.00456",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "stat.ME"
    ],
    [
      "openalex",
      "1311|Genetic Associations and Epidemiology"
    ]
  ],
  "openalex": "W7206187607",
  "pdf_url": "https://arxiv.org/pdf/2609.00456",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ej4sc1s6a1hrb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "2609.00456",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2609.00456"
    }
  ],
  "subjects": [
    {
      "field": "mathematics",
      "origin": "arxiv:stat.ME",
      "subfield": "statistics"
    }
  ],
  "title": "Genetic association testing with multivariate survival phenotypes under interval censoring",
  "title_text": "Genetic association testing with multivariate survival phenotypes under interval censoring",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/ej4sc1s6a1hrb",
  "venue": "arXiv",
  "versions": []
}