{
  "abstract": "This study reports a novel acyl-radical-promoted cascade annulation of indolyl N-cyanamides to afford spiro[indoline-pyrrolo[2,1-b]quinazolinone] frameworks. The conversion proceeds through sequential acyl radical addition, dearomative ipso-annulation by the capture of the C3-radical with an N-cyano group and quinazolinone ring formation in the presence of an oxidant in a single operation. This protocol features broad substrate scope with good functional-group tolerance and represents a highly diastereo- selective atom- and step-economical platform for the assembly of complex spirocycles integrating two bioactive scaffolds, quinazolinone and indoline, from a linear precursor.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Anootha Neeliveettil"
    },
    {
      "name": "Jannatul Islam"
    },
    {
      "name": "Luc Neuville"
    },
    {
      "name": "Geraldine Masson"
    },
    {
      "name": "Chada Raji Reddy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ejh441mhn26q1.bib",
  "cited_by": 0,
  "doi": "10.1039/d6qo00923a",
  "fulltext_url": null,
  "id": "ejh441mhn26q1",
  "issns": [
    "2052-4110",
    "2052-4129"
  ],
  "landing_url": "https://hal.science/hal-05763576v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.orga"
    ],
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7207762768",
  "pdf_url": "https://hal.science/hal-05763576/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/ejh441mhn26q1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:40Z",
      "native_id": "hal-05763576",
      "source": "hal",
      "url": "https://hal.science/hal-05763576v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.orga",
      "subfield": "organic"
    }
  ],
  "title": "A radical cascade via dearomative ipso -annulation of indolyl N -cyanamides: access to spiro[indoline-pyrroloquinazolinones]",
  "title_text": "A radical cascade via dearomative ipso -annulation of indolyl N -cyanamides: access to spiro[indoline-pyrroloquinazolinones]",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:40Z",
  "url": "https://research.draconitic.com/paper/ejh441mhn26q1",
  "venue": "Organic Chemistry Frontiers",
  "versions": []
}