{
  "abstract": "P-type ATPases are conserved ATP-driven ion transporters that maintain cellular ion homeostasis. Plant P-type IIB Ca2+-ATPases, known as autoinhibited Ca2+-ATPases (ACAs), are key regulators of Ca2+ signaling networks. This review summarizes the structural features, Ca2+/calmodulin-dependent regulation, evolutionary diversification, and biological functions of plant ACAs. By contributing to cytosolic Ca2+ clearance and the restoration of basal Ca2+ levels, ACAs may modulate stimulus-specific Ca2+ dynamics and participate in diverse physiological processes, including plant growth, development, stomatal movement, immunity, and abiotic stress adaptation. Comparative analyses across plant species highlight functional specialization of ACA isoforms and their potential value for crop improvement. We further discuss current challenges in ACA functional characterization, particularly the complexity of Ca2+ signaling networks and the limited understanding of ACA-associated genetic variation. Emerging approaches integrating multi-omics, artificial intelligence, and precision genome editing provide new opportunities for identifying and designing ACA alleles for climate-resilient crop breeding.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Mengmeng Rui"
    },
    {
      "name": "Dongdong Xu"
    },
    {
      "name": "Yongsheng Deng"
    },
    {
      "name": "Yizhou Wang"
    },
    {
      "name": "Zongfu Han"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ejz7szpvxbdav.bib",
  "cited_by": 0,
  "doi": "10.3389/fpls.2026.1984800",
  "fulltext_url": null,
  "id": "ejz7szpvxbdav",
  "issns": [
    "1664-462X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpls.2026.1984800",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "biology/plant-biology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ejz7szpvxbdav.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T18:20:59Z",
      "native_id": "10.3389/fpls.2026.1984800",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fpls.2026.1984800"
    },
    {
      "first_seen": "2026-11-07T00:21:17Z",
      "native_id": "10.3389/fpls.2026.1984800",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpls.2026.1984800/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "feed-journal:biology/plant-biology",
      "subfield": "plant-biology"
    }
  ],
  "title": "Plant autoinhibited Ca2+-ATPases: shaping calcium signals for growth, stress adaptation, and crop improvement",
  "title_text": "Plant autoinhibited Ca2+-ATPases: shaping calcium signals for growth, stress adaptation, and crop improvement",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T00:22:47Z",
  "url": "https://research.draconitic.com/paper/ejz7szpvxbdav",
  "venue": "Frontiers in Plant Science",
  "versions": []
}