{
  "abstract": "Purpose: Pancreatic carcinoma (PC) and biliary tract carcinoma (BTC) may metastasize to the lungs, and surgical resection of these metastases should be considered in selected patients with controlled primary disease. This study evaluated the survival outcomes and prognostic factors in patients who underwent pulmonary metastasectomy for pancreatobiliary carcinoma.\n\nMethods: Seventy-eight patients who underwent lung metastasectomy between 1993 and 2019 were included in the Metastatic Lung Tumor Study Group of the Japan database. The clinicopathological characteristics including overall survival (OS), pulmonary metastasis-free survival (PmFS), and disease-free interval (DFI) from primary surgery to lung metastasectomy were analyzed.\n\nResults: We included 41 men and 37 women with a mean age of 67 years. The primary cancers included 56 PC and 22 BTC cases. Partial resection was performed in 52 patients, segmentectomy in 16, and lobectomy in 10. Five-year OS was 38.3% (43.2% for PC and 28.1% for BTC). Five-year PmFS was 28.3% (28.4% for PC and 27.7% for BTC). The median DFI was 36.0 months (21.0–47.5 months, interquartile range). Larger metastases (> 2 cm) were significantly associated with a poorer survival (hazard ratio, 2.03; 95% confidence interval, 1.06–3.90, p = 0.03).\n\nConclusion: Lung metastasectomy may be a viable treatment option for select patients with pancreatobiliary carcinoma, particularly those with smaller metastases.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00595-026-03389-8.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670 Japan",
    "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan",
    "Department of Thoracic Surgery, Aichi Cancer Center, Aichi, Japan",
    "Department of Thoracic Surgical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan",
    "Department of Thoracic Surgery, National Defense Medical College, Saitama, Japan",
    "Division of Thoracic Surgery, Chiba Cancer Center, Chiba, Japan",
    "Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan",
    "Department of General Thoracic Surgery, Dokkyo Medical University, Tochigi, Japan",
    "Division of Thoracic Surgery, Tochigi Cancer Center, Tochigi, Japan",
    "Division of Thoracic Surgery, Department of Surgery, Keio University School of Medicine, Tokyo, Japan",
    "Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan",
    "Department of Thoracic Surgery, Kimitsu Chuo Hospital, Chiba, Japan",
    "Department of General Thoracic Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan",
    "Division of Thoracic and Thyroid Surgery, Kyorin University, Tokyo, Japan",
    "Division of Thoracic and Thyroid Surgery, Tokyo Medical University, Tokyo, Japan",
    "Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Taisuke Kaiho"
    },
    {
      "affs": [
        0
      ],
      "name": "Takahide Toyoda"
    },
    {
      "affs": [
        0
      ],
      "name": "Hidemi Suzuki",
      "orcid": "0000-0002-8983-433X"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoshikane Yamauchi"
    },
    {
      "affs": [
        2
      ],
      "name": "Noriaki Sakakura"
    },
    {
      "affs": [
        3
      ],
      "name": "Mingyon Mun"
    },
    {
      "affs": [
        4
      ],
      "name": "Hiroshi Hashimoto"
    },
    {
      "affs": [
        5
      ],
      "name": "Takekazu Iwata"
    },
    {
      "affs": [
        6
      ],
      "name": "Yasushi Shintani"
    },
    {
      "affs": [
        7
      ],
      "name": "Masayuki Chida"
    },
    {
      "affs": [
        8
      ],
      "name": "Haruhisa Matsuguma"
    },
    {
      "affs": [
        9
      ],
      "name": "Keisuke Asakura"
    },
    {
      "affs": [
        10
      ],
      "name": "Makoto Endo"
    },
    {
      "affs": [
        11
      ],
      "name": "Tomohiko Iida"
    },
    {
      "affs": [
        12
      ],
      "name": "Mitsutomo Kohno"
    },
    {
      "affs": [
        13
      ],
      "name": "Haruhiko Kondo"
    },
    {
      "affs": [
        14
      ],
      "name": "Norihiko Ikeda"
    },
    {
      "affs": [
        15
      ],
      "name": "Masaaki Sato"
    },
    {
      "affs": [
        1
      ],
      "name": "Yukinori Sakao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ek97pn1f98b3j.bib",
  "cited_by": 0,
  "doi": "10.1007/s00595-026-03389-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722726/",
  "id": "ek97pn1f98b3j",
  "issns": [
    "0941-1291",
    "1436-2813"
  ],
  "landing_url": "https://doi.org/10.1007/s00595-026-03389-8",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7169813451",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00595-026-03389-8.pdf",
  "pmcid": "PMC13722726",
  "pmid": "42474769",
  "published": "2026-07-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ek97pn1f98b3j.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:29Z",
      "native_id": "PMC13722726",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00595-026-03389-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Pancreatic and Hepatic Oncology Research",
      "subfield": "oncology"
    }
  ],
  "title": "Survival after pulmonary metastasectomy for pancreatobiliary carcinomas: insights from a nationwide multicenter database",
  "title_text": "Survival after pulmonary metastasectomy for pancreatobiliary carcinomas: insights from a nationwide multicenter database",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:29Z",
  "url": "https://research.draconitic.com/paper/ek97pn1f98b3j",
  "venue": "Surgery Today",
  "versions": []
}