{
  "abstract": "BackgroundSLC25A28 encodes the mitochondrial iron transporter mitoferrin-2, but its prognostic relevance and biological associations in glioma remain incompletely characterized. We investigated its clinical significance and relationships with metabolic, ferroptosis-related and immune features across glioma cohorts.MethodsSLC25-family genes were screened in CGGA and TCGA, followed by survival analysis and meta-analysis across nine GlioVis cohorts. Clinical Cox models, prognostic scores and grade/IDH subgroups were evaluated. Metabolic, immune and curated ferroptosis-related signatures were examined using clinically adjusted models, and immune-cell and checkpoint analyses underwent false-discovery-rate correction. SLC25A28 expression was assessed by qRT-PCR and Western blotting.ResultsLower SLC25A28 expression was associated with unfavorable clinicopathological features and shorter overall survival (pooled hazard ratio, 1.91; 95% confidence interval, 1.46–2.50; I² = 84.9%). Exploratory analyses supported survival associations in both IDH-mutant and IDH-wild-type subgroups of CGGA and TCGA, although findings within glioblastoma varied. Positive oxidative-phosphorylation associations persisted after grade/IDH adjustment in both pooled cohorts; within glioblastoma, this association was supported in CGGA but not TCGA. Ferroptosis-related transcriptional associations were also detected, with consistent all-glioma WikiPathways results across sensitivity analyses in TCGA but scoring-method and cohort dependence in regulator signatures. Immune-cell differences survived correction for 10 of 22 populations in CGGA and 16 of 22 in TCGA, and three checkpoint genes showed positive correlations in both cohorts. qRT-PCR and Western blotting confirmed lower SLC25A28 expression in U87 and U251 cells than in normal human astrocytes.ConclusionsSLC25A28 is a candidate prognostic biomarker associated with mitochondrial metabolism, ferroptosis-related transcriptional features and immune features in glioma. Multi-cohort survival evidence and clinically adjusted molecular associations support further evaluation of its prognostic and biological relevance. Subtype-specific clinical validation and functional investigations will help define its clinical utility and biological role.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Original Research",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Wangyang Yu"
    },
    {
      "name": "Yue Yang"
    },
    {
      "name": "Wenli Guo"
    },
    {
      "name": "Yafeng Wang"
    },
    {
      "name": "Jinsong Bai"
    },
    {
      "name": "Chen Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ekeq1snrz8rc1.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1917001",
  "fulltext_url": null,
  "id": "ekeq1snrz8rc1",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1917001",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/oncology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ekeq1snrz8rc1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.3389/fonc.2026.1917001",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1917001"
    },
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "10.3389/fonc.2026.1917001",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1917001/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Prognostic significance of SLC25A28 and its associations with mitochondrial metabolism and immune features in glioma",
  "title_text": "Prognostic significance of SLC25A28 and its associations with mitochondrial metabolism and immune features in glioma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T00:21:05Z",
  "url": "https://research.draconitic.com/paper/ekeq1snrz8rc1",
  "venue": "Frontiers in Oncology",
  "versions": []
}