{
  "abstract": "Neuroimaging studies have reported that chronic pain may be associated with brain functional changes and related molecular mechanisms. However, there are few studies in anterior shoulder pain (ASP). Thus, we aimed to assess the possible brain functional changes and their associations with neurotransmitter receptor maps in ASP patients. Resting-state functional magnetic resonance imaging data were obtained from 27 ASP patients and 20 healthy controls (HCs). Regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF) methods were used to examine altered brain functions. JuSpace toolbox was employed for evaluating the spatial correlations between ReHo and fALFF changes and neurotransmitter receptor maps. Regression analysis was conducted to explore the associations between neuroimaging findings and clinical characteristics in ASP patients. Furthermore, we investigated reliable biomarkers to distinguish ASP patients from HCs using receiver operating characteristic (ROC) curve analysis. ASP patients had abnormal ReHo/fALFF in the middle temporal gyrus, putamen, caudate, pallidum, precentral gyrus, medial prefrontal cortex, precuneus, posterior cingulate cortex and inferior temporal gyrus. ReHo/fALFF alterations in ASP patients were associated with the serotonin, dopamine, GABA, choline, glutamate and norepinephrine neurotransmitter systems. Visual analog scale was positively correlated with ReHo in the right insula. Moreover, ROC analysis showed higher classification accuracy in the middle temporal gyrus, precentral gyrus and putamen. Our study investigated abnormal brain function and associated neurotransmitter receptor maps in ASP patients, which may contribute to improving our understanding of the pathophysiological mechanisms in ASP.",
  "abstract_shown": true,
  "affiliations": [
    "Shaanxi Key Laboratory of Acupuncture and Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China.",
    "Department of Rehabilitation, 3201 Hospital Affiliated to Xi'an Jiaotong University, Hanzhong, Shaanxi, 723000, China.",
    "School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.",
    "Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, China.",
    "The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China.",
    "Shaanxi Key Laboratory of Acupuncture and Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China. 1511006@sntcm.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhijun Diao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huan Li"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yujia Li"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Chengxiang Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Yunsong Zheng"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Jingdong Lu"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yintao Liu"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Zi Wei"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Peng Liu"
    },
    {
      "affs": [
        5
      ],
      "name": "Haifa Qiao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ekhg9na9yex1m.bib",
  "cited_by": 0,
  "doi": "10.1007/s11682-026-01171-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13680527",
  "id": "ekhg9na9yex1m",
  "issns": [
    "1931-7557",
    "1931-7565"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897350",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Pain Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7222967762",
  "pdf_url": "https://europepmc.org/articles/PMC13680527?pdf=render",
  "pmcid": "PMC13680527",
  "pmid": "42897350",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ekhg9na9yex1m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42897350",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897350"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Pain Mechanisms and Treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Altered brain function and its spatial correlations with neurotransmitter maps in anterior shoulder pain patients.",
  "title_text": "Altered brain function and its spatial correlations with neurotransmitter maps in anterior shoulder pain patients.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/ekhg9na9yex1m",
  "venue": "Brain imaging and behavior",
  "versions": []
}