{
  "abstract": "The snail, Oncomelania hupensis, is the only intermediate host of Schistosoma japonicum. Thus, snail control is one of the most rapid and effective strategies for disrupting schistosomiasis transmission. In this study, 125 botanical extracts were screened for molluscicidal activity, leading to the selection of the extract of Helleborus thibetanus (EHT) for further evaluation. EHT exhibited strong molluscicidal activity against O. hupensis (LC50 value of 12.54 mg/L and LD50 value of 1.400 g/m2). In field trials, an EHT dose of 10 g/m2 killed 85.19% of the snails. Histopathological evaluation revealed that EHT caused comprehensive damage to the cephalopodium, gill, salivary gland, stomach, and hepatopancreas. Importantly, EHT was also generally safe for non-target organisms, such as Danio rerio, Daphnia magna, Pelophylax nigromaculatus, Cipangopaludina chinensis, and Neocaridina denticulata at the test concentration. These results suggest the potential of EHT as an effective and eco-friendly molluscicide for the control of O. hupensis.",
  "abstract_shown": true,
  "affiliations": [
    "National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Haonan Yu"
    },
    {
      "name": "Guoli Qu"
    },
    {
      "name": "Liping Wang"
    },
    {
      "name": "Jiankun Jin"
    },
    {
      "name": "Yuntian Xing"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ekkgrst7dmqtt.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0354674",
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  "id": "ekkgrst7dmqtt",
  "issns": [
    "1932-6203"
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  "landing_url": "https://doi.org/10.1371/journal.pone.0354674",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
    [
      "openalex",
      "1109|Mollusks and Parasites Studies"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Animal anatomy/Aquatic respiratory anatomy/Gills"
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      "plos",
      "/Biology and life sciences/Anatomy/Digestive system/Salivary glands"
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    [
      "plos",
      "/Biology and life sciences/Anatomy/Exocrine glands/Salivary glands"
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    [
      "plos",
      "/Biology and life sciences/Anatomy/Respiratory system/Gills"
    ],
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      "/Biology and life sciences/Nutrition/Diet/Food/Flour"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Eukaryota/Animals/Invertebrates/Molluscs/Gastropods/Snails"
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      "plos",
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    [
      "plos",
      "/Biology and life sciences/Zoology/Animals/Invertebrates/Molluscs/Gastropods/Snails"
    ],
    [
      "plos",
      "/Biology and life sciences/Zoology/Animals/Vertebrates/Fish/Osteichthyes/Zebrafish"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Animal anatomy/Aquatic respiratory anatomy/Gills"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Digestive system/Salivary glands"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Exocrine glands/Salivary glands"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Respiratory system/Gills"
    ],
    [
      "plos",
      "/Medicine and health sciences/Nutrition/Diet/Food/Flour"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Toxicology/Toxicity"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Animal models/Zebrafish"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Model organisms/Zebrafish"
    ],
    [
      "plos",
      "/Research and analysis methods/Model organisms/Zebrafish"
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      "plos",
      "/Research and analysis methods/Research design/Field trials"
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  "openalex": "W7212248116",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0354674&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/ekkgrst7dmqtt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pone.0354674",
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      "url": "https://doi.org/10.1371/journal.pone.0354674"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Effects of Helleborus thibetanus extract, a novel plant-derived molluscicide on Oncomelania hupensis, the intermediate host of Schistosoma japonicum",
  "title_text": "Effects of Helleborus thibetanus extract, a novel plant-derived molluscicide on Oncomelania hupensis, the intermediate host of Schistosoma japonicum",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/ekkgrst7dmqtt",
  "venue": "PLOS One",
  "versions": []
}