{
  "abstract": "This study evaluated whether chronic aerobic exercise could attenuate behavioral impairments associated with sleep deprivation (SD) in young and aged male mice. Young (3 months) and aged (18 months) Swiss mice were assigned to four groups: control, exercise (EXE), sleep deprivation (SD), and exercise followed by SD (EXE + SD). Animals performed treadmill training for 8 weeks and then underwent 72-hour SD. Behavioral tests assessed working memory (Y-maze), depression-like behavior (tail suspension), and anxiety-like behavior (elevated plus maze). The results suggest that age influences the effectiveness of exercise in mitigating sleep deprivation-induced behavioral deficits, opening avenues for future studies on the interaction between physical exercise, sleep, and aging.",
  "abstract_shown": true,
  "affiliations": [
    "Sleep and Biological Rhythms Laboratory, Federal University of Ceara (UFC), Fortaleza, Brazil.",
    "Postgraduate Program in Medical Sciences, Federal University of Ceara (UFC), Fortaleza, Brazil.",
    "Universidade Nilton Lins, Parque das Laranjeiras, Manaus, Brazil.",
    "Laboratory of Wound Healing, Ontogeny, and Tissue Nutrition, Federal University of Ceara (UFC), Fortaleza, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Robson Salviano de Matos",
      "orcid": "0000-0003-1349-8170"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Paulo Iury Gomes Nunes",
      "orcid": "0000-0003-2996-4340"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bruna Rafaele Diógenes da Silva",
      "orcid": "0000-0001-8206-4355"
    },
    {
      "affs": [
        2
      ],
      "name": "Daniel Vieira Pinto",
      "orcid": "0000-0001-7846-7258"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pedro Felipe Carvalhedo de Bruin",
      "orcid": "0000-0001-9694-1523"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Reinaldo Barreto Oriá",
      "orcid": "0000-0002-6914-5481"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Veralice Meireles Sales de Bruin",
      "orcid": "0000-0003-1575-6823"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ekpy0k7xw7w7v.bib",
  "cited_by": 0,
  "doi": "10.1055/s-0046-1829073",
  "fulltext_url": "https://europepmc.org/articles/PMC13680043",
  "id": "ekpy0k7xw7w7v",
  "issns": [
    "1984-0659",
    "1984-0063"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899062",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Sleep and Wakefulness Research"
    ]
  ],
  "openalex": "W7222913523",
  "pdf_url": "https://europepmc.org/articles/PMC13680043?pdf=render",
  "pmcid": "PMC13680043",
  "pmid": "42899062",
  "published": "2026-06-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ekpy0k7xw7w7v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42899062",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899062"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Sleep and Wakefulness Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation.",
  "title_text": "Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:42Z",
  "url": "https://research.draconitic.com/paper/ekpy0k7xw7w7v",
  "venue": "Sleep science (Sao Paulo, Brazil)",
  "versions": []
}