{ "abstract": "Background: Population-based evidence on Breast Cancer (BC) survival and disease burden in Tunisia remains limited. This study aimed to describe BC survival and temporal trends, quantify the BC burden, and assess the impact of early diagnosis on survival and burden. Methods: We conducted a descriptive population-based cohort study of women diagnosed with BC in Monastir between 2002 and 2014, with follow-up through January 2022. Overall survival was estimated using Kaplan-Meier methods, and factors associated with mortality were assessed using multivariable Cox regression. BC burden was quantified using disability-adjusted life years (DALYs), comprising years of life lost (YLLs) and years lived with disability (YLDs). Relative risks (RRs) and related measures were used to assess the association between stage at diagnosis and mortality. Results: Among 1,075 incident BC cases identified between 2002 and 2014, 21.4% were diagnosed at stage IV. By 2022, vital status information was available for 959 women. The crude and age-standardized mortality rates were 11.9 (95% CI, 8.5–15.4) and 12.5 (95% CI, 8.9–16.0) per 100,000 WY, respectively. Median survival was 187 months (95% CI, 163.7–210.2), reaching 226 months among women diagnosed at stages 0–I. Three-, five-, and ten-year survival rates were 77.0%, 70.0%, and 45.2%, respectively. Ten-year relative survival showed a significant upward trend among women aged 30–64 years, corresponding to the target population of the national BC early detection program (APC, 5.37%; 95% CI, 2.03–8.82; p = 0.005). The total BC burden was 10,665.4 DALYs, including 10,362 YLLs (97.3%). Median DALYs per patient was 28.0 years (IQR, 13.74–36.95). Diagnosis at stages 0–II was associated with a 22% reduction in ten-year mortality (RR, 0.78; 95% CI, 0.67–0.91), with an NND of 9. Diagnosing 61 women at stages 0–II rather than III–IV would avoid one DALY. Conclusion: The significant upward trend in ten-year survival among women targeted by the national BC early detection program, together with the avoidance of one DALY per 61 women diagnosed at stages 0–II rather than III–IV, supports continued investment in early detection and BC control in Tunisia.", "abstract_shown": true, "affiliations": [ "Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba Hospital of Monastir, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Technology and Medical Imaging Research Laboratory - LTIM - LR12ES06, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Department of Hematology, University maternity Center of Monastir, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Department of Hospital Hygiene, Fattouma Bourguiba Hospital of Monastir, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Department of community and Preventive Medicine Regional Hospital of Ksar Hellal, University of Monastir, Faculty of Medicine of Monastir, MonastirTunisia", "Department of Family Medicine, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Department of Radiology, University Maternity Center of Monastir, University of Monastir, Faculty oF Medicine of Monastir, Monastir, Tunisia", "Department of Pathology, Fattouma Bourguiba Hospital of Monastir, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Department of Oncology, University Maternity Center of Monastir, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Department of Gynecology, University Maternity Center of Monastir, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia", "Cancer Registry of the Center of Tunisia, University Hospital Farhat Hached of Sousse, University of Sousse, Sousse, Tunisia", "Department of Reproductive Biology, University Maternity Center of Monastir, University of Monastir, Faculty of Medicine of Monastir, Monastir, Tunisia" ], "article_type": "Research Article", "arxiv": null, "author_total": 20, "authors": [ { "affs": [ 0 ], "name": "Imen Zemni" }, { "affs": [ 1 ], "name": "Amani Maatouk" }, { "affs": [ 2 ], "name": "Wiem Boufrikha" }, { "affs": [ 3 ], "name": "Cyrine Bennasrallah" }, { "affs": [ 4 ], "name": "Wafa Dhouib" }, { "affs": [ 5 ], "name": "Meriem Kacem" }, { "affs": [ 6 ], "name": "Hela Abroug" }, { "affs": [ 7 ], "name": "Manel Ben Fredj" }, { "affs": [ 8 ], "name": "Inès Bouanene" }, { "affs": [ 9 ], "name": "Islem Jridi" }, { "affs": [ 10 ], "name": "Hiba Arfa" }, { "affs": [ 11 ], "name": "Amina Ben Salem" }, { "name": "Leila Njim" }, { "name": "Sonia Zaied" }, { "name": "Raja Faleh" }, { "name": "Karawen Sakka" }, { "name": "Badreddine Sriha" }, { "name": "Lilia Jaîdane" }, { "name": "Meriem Mehdi" }, { "name": "Asma Belguith Sriha" } ], "bibtex": "https://research.draconitic.com/paper/ekrn10wwtpmv8.bib", "cited_by": 0, "doi": "10.1371/journal.pone.0360398", "fulltext_url": null, "id": "ekrn10wwtpmv8", "issns": [ "1932-6203" ], "landing_url": "https://doi.org/10.1371/journal.pone.0360398", "language": null, "licence": "CC-BY-4.0", "licence_label": "CC BY 4.0", "licence_source": "journal", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "2730|Global Cancer Incidence and Screening" ], [ "plos", "/Biology and life sciences/Anatomy/Histology" ], [ "plos", "/Biology and life sciences/Population biology/Population metrics/Death rates" ], [ "plos", "/Medicine and health sciences/Anatomy/Histology" ], [ "plos", "/Medicine and health sciences/Diagnostic medicine/Cancer detection and diagnosis" ], [ "plos", "/Medicine and health sciences/Oncology/Cancer detection and diagnosis" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms/Breast tumors/Breast cancer" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms/Breast tumors/Invasive ductal carcinoma" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms/Carcinoma/Invasive ductal carcinoma" ], [ "plos", "/Medicine and health sciences/Public and occupational health" ], [ "plos", "/People and places/Geographical locations/Africa/Tunisia" ], [ "plos", "/People and places/Population groupings/Age groups" ] ], "openalex": "W7221799734", "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0360398&type=printable", "pmcid": null, "pmid": null, "published": "2026-10-14", "publisher": "Public Library of Science", "ris": "https://research.draconitic.com/paper/ekrn10wwtpmv8.ris", "sources": [ { "first_seen": "2026-10-30T12:17:23Z", "native_id": "10.1371/journal.pone.0360398", "source": "plos", "url": "https://doi.org/10.1371/journal.pone.0360398" } ], "subjects": [ { "field": "medicine", "origin": "plos:oncology", "subfield": "oncology" }, { "field": "medicine", "origin": "plos:anatomy", "subfield": "physiology" } ], "title": "Survival and disease burden of breast cancer (Monastir, Tunisia): A population-based cohort study (2002–2022)", "title_text": "Survival and disease burden of breast cancer (Monastir, Tunisia): A population-based cohort study (2002–2022)", "type": "peer-reviewed", "updated_at": "2026-10-30T12:17:23Z", "url": "https://research.draconitic.com/paper/ekrn10wwtpmv8", "venue": "PLOS One", "versions": [] }