{
  "abstract": "Oral surgical wounds may benefit from local biomaterials capable of delivering bioactive compounds while remaining compatible with gingival cells. This study evaluated type A gelatin hydrogels containing turmeric powder (1.5, 3.1, or 12.5 mg per preparation) and a separate series prepared with a 25 mg/mL turmeric stock in dimethyl sulfoxide (DMSO). The hydrogels were assessed for macroscopic integrity, supernatant absorbance, MTT responses in human gingival fibroblasts (HGFs), prostaglandin E₂ (PGE₂), and exploratory microbial response against Staphylococcus aureus and Candida albicans. Powder-loaded matrices lost macroscopic integrity within approximately 45 min in PBS and 30 min in trypsin. Powder-loaded formulations generally produced MTT signals near control values, whereas several DMSO-stock formulations showed lower signals at later exposures. PGE₂ did not show consistent dose-dependent suppression after normalization of the corresponding MTT-derived relative metabolic signal. Agar diffusion showed an approximate 2.4 mm clearance beyond the specimen edge against S. aureus for the 1.5 mg formulation and none against C. albicans; the gelatin control also showed visible clearance, and higher turmeric loadings did not produce measurable zones. Colony recovery decreased across the DMSO-stock formulations, but most plate counts were below the conventional countable range and were therefore interpreted descriptively. Overall, the findings provide an early in vitro characterization of rapidly disintegrating gelatin-turmeric hydrogels and identify matrix stability and assay limitations as major constraints that require further validation.",
  "abstract_shown": true,
  "affiliations": [
    "Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, National School of Higher Studies (ENES), National Autonomous University of Mexico (UNAM), Leon 37684, Guanajuato, Mexico.",
    "Faculty of Stomatology, Autonomous University of San Luis Potosí, San Luis Potosi 78290, San Luis Potosí, Mexico.",
    "School of Dental Medicine, Ponce Health Sciences University, Ponce 00716, Puerto Rico.",
    "College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.",
    "Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yareth Idalia Ayerim Gutierrez-Jimenez",
      "orcid": "0009-0006-7241-217X"
    },
    {
      "affs": [
        0
      ],
      "name": "Rene Garcia-Contreras",
      "orcid": "0000-0003-3504-5519"
    },
    {
      "affs": [
        0
      ],
      "name": "Paloma Netzayeli Serrano-Diaz",
      "orcid": "0000-0001-9684-7991"
    },
    {
      "affs": [
        1
      ],
      "name": "Juan Carlos Flores-Arriaga",
      "orcid": "0000-0001-5998-7928"
    },
    {
      "affs": [
        0
      ],
      "name": "Ravichandran Manisekaran",
      "orcid": "0000-0002-2934-0717"
    },
    {
      "affs": [
        2
      ],
      "name": "Carlos A Jurado",
      "orcid": "0000-0001-7437-4855"
    },
    {
      "affs": [
        2
      ],
      "name": "Silvia Rojas-Rueda"
    },
    {
      "affs": [
        3
      ],
      "name": "Abdullah Almansour"
    },
    {
      "affs": [
        4
      ],
      "name": "Abdulrahman Alshabib",
      "orcid": "0000-0001-8890-8707"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/emhz36rr0gwy9.bib",
  "cited_by": 0,
  "doi": "10.3390/gels12100927",
  "fulltext_url": "https://europepmc.org/articles/PMC13704384",
  "id": "emhz36rr0gwy9",
  "issns": [
    "2310-2861"
  ],
  "landing_url": "https://europepmc.org/article/MED/42929961",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7222215271",
  "pdf_url": "https://europepmc.org/articles/PMC13704384?pdf=render",
  "pmcid": "PMC13704384",
  "pmid": "42929961",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/emhz36rr0gwy9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929961",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929961"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Turmeric-Loaded Type A Gelatin Hydrogels: In Vitro Assessment for Oral Wound Management Applications.",
  "title_text": "Turmeric-Loaded Type A Gelatin Hydrogels: In Vitro Assessment for Oral Wound Management Applications.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/emhz36rr0gwy9",
  "venue": "Gels (Basel, Switzerland)",
  "versions": []
}