{
  "abstract": "Clazosentan (CLA), an endothelin-A receptor antagonist, is used to prevent cerebral vasospasm (CV) following subarachnoid hemorrhage (SAH). Although its efficacy has been demonstrated in large-scale clinical trials, the effects of CLA on cytokine and chemokine profiles in cerebrospinal fluid (CSF) after SAH remain unclear. Twenty-two patients with SAH were enrolled. Ten patients received fasudil hydrochloride (FH), a Rho kinase inhibitor, and 12 received CLA. CSF samples were collected on days 1, 3, 5, 7, 10, and 14. Concentrations of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), interferon-γ–inducible protein-10 (IP-10), and monokine induced by interferon-γ (MIG) were measured using enzyme-linked immunosorbent assay. IL-6 levels were significantly suppressed during the acute phase in the CLA group compared with the FH group, whereas MCP-1 levels were upregulated on day 1. The peak expression of IP-10 and MIG was delayed in the CLA group relative to the FH group. A strong correlation between IP-10 and MIG was observed on day 5 in the FH group and on day 7 in the CLA group. CLA suppressed IL-6 expression during the acute phase, which may contribute to delayed upregulation of IP-10 and MIG. Suppression of IL-6 may represent a key mechanism underlying the anti-inflammatory effects of CLA following SAH.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurological Surgery, Aichi Medical University, Nagakute, Aichi, Japan"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Toshiaki INOMO"
    },
    {
      "affs": [
        0
      ],
      "name": "Koji OSUKA"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenichiro IWAMI"
    },
    {
      "affs": [
        0
      ],
      "name": "Eiji ITO"
    },
    {
      "affs": [
        0
      ],
      "name": "Tetsuya IOKU"
    },
    {
      "affs": [
        0
      ],
      "name": "Tadashi WATANABE"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/emvsyrq0rk1eq.bib",
  "cited_by": 0,
  "doi": "10.2176/jns-nmc.2026-0047",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731933/",
  "id": "emvsyrq0rk1eq",
  "issns": [
    "0470-8105",
    "1349-8029"
  ],
  "landing_url": "https://doi.org/10.2176/jns-nmc.2026-0047",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Rapid Communication"
    ],
    [
      "openalex",
      "2728|Intracranial Aneurysms: Treatment and Complications"
    ]
  ],
  "openalex": "W7211930479",
  "pdf_url": "https://www.jstage.jst.go.jp/article/nmc/advpub/0/advpub_2026-0047/_pdf",
  "pmcid": "PMC13731933",
  "pmid": "42716758",
  "published": "2026-09-09",
  "publisher": "Japan Neurosurgical Society",
  "ris": "https://research.draconitic.com/paper/emvsyrq0rk1eq.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:02Z",
      "native_id": "PMC13731933",
      "source": "pmc",
      "url": "https://doi.org/10.2176/jns-nmc.2026-0047"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracranial Aneurysms: Treatment and Complications",
      "subfield": "neurology"
    }
  ],
  "title": "Clazosentan, Endothelin-A Receptor Antagonist, Suppresses Interleukin-6 Expression in Cerebrospinal Fluid after Subarachnoid Hemorrhage",
  "title_text": "Clazosentan, Endothelin-A Receptor Antagonist, Suppresses Interleukin-6 Expression in Cerebrospinal Fluid after Subarachnoid Hemorrhage",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:02Z",
  "url": "https://research.draconitic.com/paper/emvsyrq0rk1eq",
  "venue": "Neurologia medico-chirurgica",
  "versions": []
}