{
  "abstract": "Biofluid proteins are promising transdiagnostic markers for delineating disease heterogeneity in psychosis. This study examined proteomic profiles in a transdiagnostic early psychosis sample to test the hypothesis that psychosis is associated with proteomic signatures of premature aging. We analyzed proteomic data from 85 individuals with early psychosis and 35 healthy controls from the Human Connectome Project for Early Psychosis (HCP-EP), using the Olink platform across four validated panels (Cardiometabolic, Inflammation, Cardiovascular II, and III). Our dual analytic strategy included: (1) calculating an index based on senescence-associated secretory phenotype (SASP) proteins to assess cellular aging, and (2) analyzing 341 proteins using Gene Set Enrichment Analysis to identify whether predefined biological pathways are collectively enriched. We compared the SASP index and enriched pathways between groups and examined associations with sociodemographic, physical health, cognitive, psychological well-being, psychosocial functioning, symptom, and medication data. The SASP index was significantly elevated in the psychosis group. Pathway analyses revealed enrichment of two inflammation-related pathways in psychosis after multiple comparison correction: Cellular Response to Tumor Necrosis Factor and Monocyte Chemotaxis. The higher SASP index and the enriched inflammatory pathways were associated with increased body mass index (BMI) and reduced psychological well-being. Our findings are consistent with prior research linking psychosis to premature aging and an increased inflammation response. They also underscore the value of examining multiple biomarkers and biological pathways simultaneously and highlight the importance of conceptualizing psychosis as a whole-body condition. However, given the sample size, results should be considered preliminary. Larger, longitudinal studies are needed to track proteomic changes over time and assess the predictive value of these biomarkers for identifying vulnerable individuals and clinical outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry, Mass General Brigham, Harvard Medical School, Boston, MA, USA",
    "Department of Psychiatry and Psychotherapy, Psychiatry Neuroimaging Branch, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany",
    "Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada",
    "Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany",
    "Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany",
    "Département de génie logiciel et des TI, Ecole de Technologie Superieure, Montreal, QC, Canada",
    "Department of Psychiatry & Behavioral Health, Stony Brook University, Stony Brook, NY, USA",
    "Max-Planck-Institute of Psychiatry, Munich, Germany",
    "Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA",
    "Centre for Psychiatry and Psychotherapy, Justus-Liebig University Giessen, Giessen, Germany",
    "Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany",
    "Psychotic Disorders Division, McLean Hospital and Department of Psychiatry, Harvard Medical School, Boston, MA, USA",
    "Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA",
    "Indiana University School of Medicine, Indianapolis, IN, USA",
    "Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, USA",
    "Department of Neurology, Massachusetts General Hospital Wang Ambulatory Care Center, Harvard Medical School, Boston, MA, USA",
    "UConn Center on Aging, University of Connecticut, Farmington, CT, USA",
    "Department of Psychiatry, UConn School of Medicine, Farmington, CT, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 25,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Johanna Seitz-Holland"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Moritz Haaf"
    },
    {
      "affs": [
        2
      ],
      "name": "Ana Paula Mendes-Silva"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Nora Penzel"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Cornelius Berberich"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Sylvain Bouix"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael J. Coleman"
    },
    {
      "affs": [
        0
      ],
      "name": "Elana Kotler"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicholas Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Katherine E. Burdick"
    },
    {
      "affs": [
        6
      ],
      "name": "Roman Kotov"
    },
    {
      "affs": [
        3,
        7
      ],
      "name": "Peter Falkai"
    },
    {
      "affs": [
        8
      ],
      "name": "Mark Vangel"
    },
    {
      "affs": [
        1
      ],
      "name": "Gregor Leicht"
    },
    {
      "affs": [
        9
      ],
      "name": "Christoph Mulert"
    },
    {
      "affs": [
        10
      ],
      "name": "Tilo Kircher"
    },
    {
      "affs": [
        11
      ],
      "name": "Kathryn E. Lewandowski"
    },
    {
      "affs": [
        0
      ],
      "name": "Daphne Holt"
    },
    {
      "affs": [
        12
      ],
      "name": "Matcheri S. Keshavan"
    },
    {
      "affs": [
        11
      ],
      "name": "Dost Öngür"
    },
    {
      "affs": [
        13
      ],
      "name": "Alan Breier"
    },
    {
      "affs": [
        0,
        14
      ],
      "name": "Martha E. Shenton"
    },
    {
      "affs": [
        15
      ],
      "name": "Steven E. Arnold"
    },
    {
      "affs": [
        16,
        17
      ],
      "name": "Breno S. Diniz"
    },
    {
      "affs": [
        0,
        14
      ],
      "name": "Marek Kubicki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/enmeym6ss5az2.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bbi.2026.107023",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13742304/",
  "id": "enmeym6ss5az2",
  "issns": [
    "0889-1591",
    "1090-2139"
  ],
  "landing_url": "https://doi.org/10.1016/j.bbi.2026.107023",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2738|Schizophrenia research and treatment"
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  "openalex": "W7213754948",
  "pdf_url": null,
  "pmcid": "PMC13742304",
  "pmid": "42764136",
  "published": "2026-09-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/enmeym6ss5az2.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:23:10Z",
      "native_id": "PMC13742304",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bbi.2026.107023"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Schizophrenia research and treatment",
      "subfield": "psychiatry"
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  ],
  "title": "Senescence-associated-secretory phenotype proteins and inflammatory pathways are involved in psychosis: A transdiagnostic study using the Human Connectome Project for Early Psychosis (HCP-EP) data",
  "title_text": "Senescence-associated-secretory phenotype proteins and inflammatory pathways are involved in psychosis: A transdiagnostic study using the Human Connectome Project for Early Psychosis (HCP-EP) data",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:23:10Z",
  "url": "https://research.draconitic.com/paper/enmeym6ss5az2",
  "venue": "Brain, behavior, and immunity",
  "versions": []
}