{
  "abstract": "Introduction: Salmonella infection remains a pervasive diarrheal illness, particularly affecting populations in developing countries. The lack of an effective vaccine against non-typhoidal Salmonella is attributable to antigenic diversity among serotypes, incomplete understanding of protective immune mechanisms, and the difficulty in identifying conserved antigens capable of eliciting broad cross-protective immunity.\n\nMethods: To identify conserved Salmonella antigens, we established a Salmonella -specific monoclonal antibody library using heat-killed bacteria. Candidate antigens recognized by monoclonal antibodies were characterized, and their functional relevance was evaluated through analyses of bacterial growth, respiratory activity, and protective effects in a murine Salmonella infection model.\n\nResults: We identified L2-1H11, a monoclonal antibody that recognizes OppA, a conserved antigen present across multiple Salmonella serotypes. L2-1H11 was associated with suppression of bacterial growth and respiratory activity and attenuated enteritis pathology in Salmonella -infected mice.\n\nConclusion: These findings identify OppA as a conserved Salmonella antigen and suggest that it may represent a promising target for the development of subcutaneous and oral vaccines against Salmonella .",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBN)",
    "Biomanufacturing Process Research Center, National Institute of Advanced and Industrial Science and Technology (AIST)",
    "The Research Foundation for Microbial Diseases of The University of Osaka",
    "BIKEN-RIMD NGS Laboratory, Research Institute for Microbial Diseases, The University of Osaka",
    "Laboratory of Proteomics for Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition (NIBN)",
    "Graduate School of Pharmaceutical Sciences, The University of Osaka",
    "Laboratory of Functional Anatomy, Department of Life Sciences, School of Agriculture, Meiji University",
    "Graduate School of Veterinary Science, Osaka Metropolitan University",
    "Graduate School of Medicine, The University of Osaka",
    "Graduate School of Dentistry, The University of Osaka",
    "Graduate School of Science, The University of Osaka",
    "International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo",
    "Department of Microbiology and Immunology, Kobe University Graduate School of Medicine",
    "Graduate School of Biomedical and Health Sciences, Hiroshima University",
    "Research Organization for Nano and Life Innovation, Waseda University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ken Yoshii"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Koichiro Suzuki"
    },
    {
      "affs": [
        4
      ],
      "name": "Jun Adachi"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhenyu Piao"
    },
    {
      "affs": [
        0
      ],
      "name": "Eri Node"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Zilai Liu"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Takahiro Nagatake"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Koji Hosomi"
    },
    {
      "affs": [
        0,
        5,
        8,
        9,
        10,
        11,
        12,
        13,
        14
      ],
      "name": "Jun Kunisawa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ensfrgw8kervn.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1943609",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690942/?tool=EBI",
  "id": "ensfrgw8kervn",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1943609/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1106|Salmonella and Campylobacter epidemiology"
    ]
  ],
  "openalex": "W7221066784",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690942/pdf/?tool=EBI",
  "pmcid": "PMC13690942",
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ensfrgw8kervn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1943609",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1943609/full"
    },
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "PMC:PMC13690942",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13690942"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Oligopeptide-binding protein A is a potential target for combating Salmonella infection",
  "title_text": "Oligopeptide-binding protein A is a potential target for combating Salmonella infection",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:59Z",
  "url": "https://research.draconitic.com/paper/ensfrgw8kervn",
  "venue": "Frontiers in Immunology",
  "versions": []
}