{
  "abstract": "Objectives: Acute respiratory viral infections, including influenza, RSV, and SARS-CoV-2, are well-recognized as being associated with cardiovascular events (CVEs). In contrast, the cardiovascular impact of human metapneumovirus (HMPV) remains poorly characterized. We aimed to describe the prevalence of pre-existing cardiovascular diseases (CVDs) and the incidence of acute CVEs in adults with laboratory-confirmed HMPV infection. Methods: PRISMA-guided systematic literature review of MEDLINE, Embase, and Google Scholar (Jan.–2000/Sept.–2025). Observational studies and clinical trials reporting pre-existing CVDs and/or CVEs in adults (≥18 years) were included. Results: Eighteen studies met the inclusion criteria, of which nine underwent critical appraisal. Most involved hospitalized older adults. Pre-existing CVD was reported in 10%–80% of HMPV-infected patients, with chronic heart failure and coronary artery disease being the most common conditions. Acute CVEs, particularly heart failure exacerbations, occurred in 5%–25% of hospitalized patients. Underlying CVD was consistently linked to increased severity of HMPV illness, including higher rates of ICU admission and mortality. Conclusions: Acute HMPV infection frequently occurs in adults with pre-existing CVD and may be associated with CVEs in older hospitalized populations. However, evidence remains limited and largely observational. These findings highlight the need to increase awareness of the potential CV complications associated with HMPV infection. Trial registration: PROSPERO [CRD420251164583]",
  "abstract_shown": true,
  "affiliations": [
    "VBIC, Univ Montpellier, INSERM, Service des Maladies Infectieuses et Tropicales, CHU Nîmes, Nîmes, France; Correspondence to:Service Maladies infectieuses et tropicales, Centre Hospitalier Universitaire Carémeau, 4 Place du Professeur Robert-Debré, Cedex 9, 30029 Nîmes, France.",
    "PhyMedExp, INSERM, CNRS, Cardiology Department, INI-CRT, Université de Montpellier, Montpellier 34295, France",
    "AP-HP, Hôpital Cochin, CIC Cochin Pasteur, Paris, France; Inserm, CIC 1417, Paris, France; Université Paris Cité, Hôpital Cochin, CIC Cochin Pasteur, Paris, France",
    "Department of Virology, Hôpitaux Universitaires Henri Mondor, Assistance Publique - Hôpitaux de Paris, Institut Mondor, INSERM U955, Team ''Viruses, Hepatology, Cancer'', Université Paris-Est-Créteil (UPEC), Créteil, France",
    "Abelia Science, Auxerre, France",
    "Sanofi Vaccines, Lyon, France",
    "Sanofi Vaccines, Copenhagen, Denmark"
  ],
  "article_type": null,
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  "author_total": 9,
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      "name": "Paul Loubet"
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      "name": "François Roubille"
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        2
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      "name": "Odile Launay"
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        3
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      "name": "Slim Fourati"
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    {
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      "name": "Fabienne Peretz"
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    {
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      "name": "Carolina Rojido"
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      "name": "Hélène Bricout"
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    {
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        5
      ],
      "name": "Clémence Touron"
    },
    {
      "affs": [
        6
      ],
      "name": "Oliver Martyn"
    }
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  "bibtex": "https://research.draconitic.com/paper/enygap693ydta.bib",
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  "doi": "10.1016/j.jinf.2026.106843",
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  "issns": [
    "1532-2742",
    "0163-4453"
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  "landing_url": "https://doi.org/10.1016/j.jinf.2026.106843",
  "language": "en",
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  "licence_label": "CC BY 4.0",
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  "pdf_url": "https://www.journalofinfection.com/article/S0163-4453(26)00169-6/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/enygap693ydta.ris",
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      "origin": "openalex:2713|Respiratory viral infections research",
      "subfield": "epidemiology-public-health"
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  "title": "Cardiovascular outcomes and acute human metapneumovirus infection in adults: A systematic literature review",
  "title_text": "Cardiovascular outcomes and acute human metapneumovirus infection in adults: A systematic literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:53Z",
  "url": "https://research.draconitic.com/paper/enygap693ydta",
  "venue": "Journal of Infection",
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