{
  "abstract": "Background: Post-transplant infection is one of the main complications in the early stage of kidney transplantation. However, there is a lack of risk prediction tools to identify those at high risk of infection.\n\nObjective: To investigate the risk factors for invasive fungal infections (IFIs) after kidney transplantation in a single center in Guangxi region and to construct a predictive model.\n\nMethods: A total of 997 patients who underwent kidney transplantation were selected as the research subjects. Patients with IFIs after kidney transplantation were classified into the IFIs group (n = 125), while the remaining patients formed the control group (n = 872). The clinical data of the two groups were compared, and the risk factors for IFIs after kidney transplantation were analyzed using multivariate logistic stepwise forward regression. The 997 samples were randomly divided into a training set and a validation set in an 7:3 ratio. The training set was used to build the model, while the validation set was used to evaluate the model performance.\n\nResults: Heart failure (OR = 4.235), low EOS% level (OR = 0.825), high Cr level (OR = 1.003), and low Mg + level (OR = 0.198) are independent risk factors influencing the occurrence of IFIs after kidney transplantation (all P < 0.05). Based on these four risk factors, a nomogram prediction model was constructed. The AUC of the training set was 0.654 (95% CI: 0.591–0.717), with a specificity of 59.3% and a sensitivity of 65.3%. The AUC of the validation set was 0.677(95% CI: 0.583–0.770), with a specificity of 59.0% and a sensitivity of 76.6%.\n\nConclusion: Heart failure, low EOS%, high Cr level, and low Mg level are closely related to the occurrence of IFIs after kidney transplantation. The prediction model based on these risk factors has certain predictive value.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China",
    "Department of Dermatology and Venereology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, China",
    "Institute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China",
    "Guangxi Clinical Research Center for Organ Transplantation, Nanning, China",
    "Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning, China",
    "Guangxi Scientific and Technological Innovation Cooperation Base of Mycosis Prevention and Control, Nanning, China",
    "Guangxi Key Laboratory of Mycosis Prevention and Treatment, Nanning, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lulu Tang"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Jiqiu Wen"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongdi Xiong"
    },
    {
      "affs": [
        1
      ],
      "name": "Chunying Lv"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Jianhui Dong"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Ning Wen"
    },
    {
      "affs": [
        1
      ],
      "name": "Guomei Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiwen Jiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Haiju Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Cairong Yan"
    },
    {
      "affs": [
        1
      ],
      "name": "Shuangshuang Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuyang Jiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yi Wu"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Cunwei Cao"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Xuyong Sun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/epchwyem3nys4.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1850921",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696262/",
  "id": "epchwyem3nys4",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.1850921",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2725|Antifungal resistance and susceptibility"
    ]
  ],
  "openalex": "W7221475132",
  "pdf_url": "https://europepmc.org/articles/PMC13696262?pdf=render",
  "pmcid": "PMC13696262",
  "pmid": "42935554",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/epchwyem3nys4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "PMC13696262",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1850921"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42935554",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935554"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Antifungal resistance and susceptibility",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Risk factors for invasive fungal infections after kidney transplantation and the construction of a predictive model",
  "title_text": "Risk factors for invasive fungal infections after kidney transplantation and the construction of a predictive model",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:38Z",
  "url": "https://research.draconitic.com/paper/epchwyem3nys4",
  "venue": "Frontiers in Medicine",
  "versions": []
}