{
  "abstract": "Three sub-series of 3-benzylmenadiones were discovered as new antischistosomal agents. The most potent representatives, called schistodiones, exhibited IC50 values <5 μM against larvae and ex vivoSchistosoma mansoni adult worms and moderate activity per os in the S. mansoni-infected mouse model in vivo. We synthesized the putative 3-benzoylmenadione metabolites of the most active compounds and explored the possible mode(s) of action using the yeast model and the recombinant drug target S. mansoni thioredoxin-glutathione reductase. Two drug targets were identified in yeast: the yeast NADH dehydrogenase and Cox15, involved in events responsible for respiratory growth defect in yeast, respectively: (i) the bioreductive activation step producing reactive oxygen species and (ii) the heme a synthase inhibition. These two drug targets are discussed in the context of S.mansoni biology, with S. mansoni thioredoxin–glutathione reductase redox-cycling and a potential source of oxidative stress in the parasite.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratoire d’Innovation Moléculaire et Applications (LIMA), Team Bio(IN)organic and Medicinal Chemistry , UMR7042 CNRS-Université de Strasbourg-Université Haute-Alsace, European School of Chemistry, Polymers and Materials (ECPM) , 25, rue Becquerel , ,",
    "Université Paris-Saclay , CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC) , ,",
    ", Kreuzstrasse 2 , ,",
    "Department of Microbial Pathogens and Immunity , Rush University Medical Center , 1735 West Harrison Street , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jeremy Pecourneau"
    },
    {
      "affs": [
        0
      ],
      "name": "Jimmy Richard"
    },
    {
      "affs": [
        1
      ],
      "name": "Brigitte Meunier"
    },
    {
      "affs": [
        2
      ],
      "name": "Maude Dagenais"
    },
    {
      "affs": [
        2
      ],
      "name": "Cécile Häberli"
    },
    {
      "affs": [
        3
      ],
      "name": "David L. Williams"
    },
    {
      "affs": [
        2
      ],
      "name": "Jennifer Keiser"
    },
    {
      "affs": [
        0
      ],
      "name": "Elisabeth Davioud-Charvet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/epmg14vsdtjve.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c06911",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670326/?tool=EBI",
  "id": "epmg14vsdtjve",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13670326",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "2405|Parasites and Host Interactions"
    ]
  ],
  "openalex": "W7214752080",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670326/pdf/?tool=EBI",
  "pmcid": "PMC13670326",
  "pmid": null,
  "published": "2026-09-29",
  "publisher": "ACS Publications",
  "ris": "https://research.draconitic.com/paper/epmg14vsdtjve.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13670326",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13670326"
    },
    {
      "first_seen": "2026-10-31T12:20:56Z",
      "native_id": "hal-05845598",
      "source": "hal",
      "url": "https://hal.science/hal-05845598v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2405|Parasites and Host Interactions",
      "subfield": "microbiology"
    }
  ],
  "title": "Synthesis and Antischistosomal Activity Profile of Several Sub-Series of Redox-Active Lead 3‑BenzylmenadionesInvestigations of the Modes of Action in Yeast",
  "title_text": "Synthesis and Antischistosomal Activity Profile of Several Sub-Series of Redox-Active Lead 3‑BenzylmenadionesInvestigations of the Modes of Action in Yeast",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:45Z",
  "url": "https://research.draconitic.com/paper/epmg14vsdtjve",
  "venue": "ACS omega",
  "versions": []
}