{
  "abstract": "In the title com-pound, C17H18N4O4S, the pyrimidine and phenyl rings subtend an inter-planar angle of 30.05 (5)°. The ring angle at the C atom between the N atoms is very wide at 129.32 (11)° and the angles at the ring N atoms are narrow [115.58 (10) and 115.98 (10)°]. The mol-ecules are linked by two classical hy-dro-gen bonds with the amine group as donor, namely N-H⋯N≡C and N-H⋯O=C, via an inversion centre and a 21 screw axis, respectively. There are also short contacts of 3.6006 (7) Å between the centroids of pairs of pyrimidine rings across inversion centres.",
  "abstract_shown": true,
  "affiliations": [
    "Pharmaceutical Chemistry Deapartment, Faculty of Pharmacy, Capital University, Helwan, Egypt.",
    "Therapeutic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.",
    "Biochemistry and Molecular Biology, Faculty of Pharmacy, Capital University, Helwan, Egypt.",
    "Chemistry Department, Faculty of Science, Capital University, Helwan, Egypt.",
    "Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Manar M Abuzahra",
      "orcid": "0000-0001-9325-3864"
    },
    {
      "affs": [
        0
      ],
      "name": "Wafaa A Zaghary",
      "orcid": "0000-0002-9037-9696"
    },
    {
      "affs": [
        1
      ],
      "name": "Nesreen S Ahmed",
      "orcid": "0000-0001-9136-9986"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohammed A Khedr"
    },
    {
      "affs": [
        2
      ],
      "name": "Hesham R S Haffez"
    },
    {
      "affs": [
        3
      ],
      "name": "Galal H Elgemeie"
    },
    {
      "affs": [
        4
      ],
      "name": "Peter G Jones"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/epmkq4v447zva.bib",
  "cited_by": 0,
  "doi": "10.1107/s2056989026010352",
  "fulltext_url": "https://europepmc.org/articles/PMC13741359",
  "id": "epmkq4v447zva",
  "issns": [
    "2056-9890"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997400",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Crystal structures of chemical compounds"
    ]
  ],
  "openalex": "W7223066234",
  "pdf_url": "https://europepmc.org/articles/PMC13741359?pdf=render",
  "pmcid": "PMC13741359",
  "pmid": "42997400",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/epmkq4v447zva.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42997400",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997400"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Crystal structures of chemical compounds",
      "subfield": "inorganic"
    }
  ],
  "title": "Synthesis and crystal structure of ethyl 2-{[4-amino-5-cyano-6-(3,4-di-meth-oxy-phen-yl)pyrimidin-2-yl]sulfan-yl}acetate.",
  "title_text": "Synthesis and crystal structure of ethyl 2-{[4-amino-5-cyano-6-(3,4-di-meth-oxy-phen-yl)pyrimidin-2-yl]sulfan-yl}acetate.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/epmkq4v447zva",
  "venue": "Acta crystallographica. Section E, Crystallographic communications",
  "versions": []
}