{
  "abstract": "Objective: This study aimed to evaluate the maturation stages of the midpalatal (MPS) and zygomaticomaxillary (ZMS) sutures, as well as the spheno-occipital synchondrosis (SOS), in patients with pycnodysostosis (PYCD) compared with controls, and to explore their associations with age and sex.\n\nDesign: Cross-sectional study was matched by sex and age with a control group.\n\nSetting: In a secondary care center for patients with rare diseases in the state of Ceara (Brazil).\n\nParticipants: 18 participants (9 PYCD, 9 controls).\n\nInterventions: Sutures were analyzed using cone-beam computed tomography (CBCT) based on established classification systems.\n\nMain Outcome Measures: The stage of suture maturation was the main evaluation parameter. MPS and ZMS were evaluated for fusion stages, while SOS ossification was assessed using a 5-stage maturation scale. Statistical analyses included Pearson's chi-square, Fisher's exact tests, and Spearman's correlations to assess associations between suture stages and demographic or clinical variables.\n\nResults: Significant differences were observed between the groups in the maturation stages of the ZMS (p = .009) and MPS (p = .029), with earlier fusion in patients with PYCD, independent of age. SOS showed no significant differences between groups but exhibited a strong correlation with age (p = .001, r = .727). Associations with sex were observed only for the SOS (p < .001), indicating earlier fusion in females.\n\nConclusions: Our findings confirm differences in the fusion stages of the MPS, and ZMS. However, further studies are needed to better understand the influence of sex and age on suture fusion, with age being a particularly significant parameter for the SOS.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Pharmacy Dentistry and Nursing, Postgraduate Program in Dentistry, Federal University of Ceara (UFC), Fortaleza, Brazil",
    "Division of Pediatric Dentistry, School of Dentistry, Federal University of Ceara, Sobral Campus, Sobral, Brazil",
    "Division of Medical Genetics, Albert Sabin Children's Hospital, Fortaleza, Brazil",
    "Department of Orthodontics, UNC Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA",
    "Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor, MI, USA",
    "Department of Pediatric Dentistry, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cauby Maia Chaves Junior"
    },
    {
      "affs": [
        0
      ],
      "name": "Pedro Henrique Moreira Lima",
      "orcid": "0000-0003-1939-1219"
    },
    {
      "affs": [
        0
      ],
      "name": "Amanda Barbosa Pereira"
    },
    {
      "affs": [
        1
      ],
      "name": "José Luciano Pimenta Couto"
    },
    {
      "affs": [
        2
      ],
      "name": "Erlane Marques Ribeiro"
    },
    {
      "affs": [
        3
      ],
      "name": "Lucia Cevidanes"
    },
    {
      "affs": [
        4
      ],
      "name": "Fernanda Angelieri"
    },
    {
      "affs": [
        5
      ],
      "name": "Cristiane S. Fonteles",
      "orcid": "0000-0003-4197-6002"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eq6mdcvp65dct.bib",
  "cited_by": 0,
  "doi": "10.1177/10556656261438345",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724826/",
  "id": "eq6mdcvp65dct",
  "issns": [
    "1055-6656",
    "1545-1569"
  ],
  "landing_url": "https://doi.org/10.1177/10556656261438345",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Articles"
    ],
    [
      "openalex",
      "1311|Craniofacial Disorders and Treatments"
    ]
  ],
  "openalex": "W7160894284",
  "pdf_url": null,
  "pmcid": "PMC13724826",
  "pmid": "42115820",
  "published": "2026-05-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eq6mdcvp65dct.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:20Z",
      "native_id": "PMC13724826",
      "source": "pmc",
      "url": "https://doi.org/10.1177/10556656261438345"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Craniofacial Disorders and Treatments",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Craniofacial Suture Maturation in Pycnodysostosis: A CBCT-Based Assessment of the Midpalatal, Zygomaticomaxillary Sutures and the Spheno-Occipital Synchondrosis",
  "title_text": "Craniofacial Suture Maturation in Pycnodysostosis: A CBCT-Based Assessment of the Midpalatal, Zygomaticomaxillary Sutures and the Spheno-Occipital Synchondrosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:23:20Z",
  "url": "https://research.draconitic.com/paper/eq6mdcvp65dct",
  "venue": "The Cleft Palate-Craniofacial Journal",
  "versions": []
}