{
  "abstract": "Background: Acute exacerbation (AE) is the most lethal event of idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD). This exploratory study compared clinical, radiomics, and combined predictor strategies across five survival-learning algorithms for survival risk stratification.\n\nMethods: We retrospectively analyzed 78 patients with AE-IIM-ILD and divided them into a training cohort (n = 54; 20 deaths) and a held-out internal testing cohort (n = 24; 9 deaths), stratified by observed mortality event status. Three predictor strategies were evaluated: a clinical strategy comprising PaO ₂ /FiO ₂ ratio, neutrophil percentage (NEU%), and arthritis-related symptoms; a radiomics strategy comprising two selected radiomics features; and a combined strategy comprising PaO ₂ /FiO ₂ ratio, arthritis-related symptoms, and a composite radiomics score (Rad-score). Each strategy was evaluated using five survival-learning algorithms. Harrell’s concordance index (C-index) was the primary discrimination metric, with mean time-dependent area under the curve (AUC) used as a secondary measure.\n\nResults: During the 1-year follow-up, 29 deaths were observed. Performance rankings varied across predictor strategies, algorithms, and evaluation metrics. The combined-Random Survival Forest configuration demonstrated the highest training-cohort C-index among the 15 configurations. Its mean time-dependent AUC was 0.923 (95% CI: 0.860–0.970) in the training cohort and 0.915 (95% CI: 0.736–0.986) in the testing cohort, with corresponding C-indices of 0.874 (95% CI: 0.803–0.940) and 0.842 (95% CI: 0.673–0.971), respectively. The model stratified patients into high- and low-risk groups with distinct observed survival trajectories.\n\nConclusion: In this exploratory cohort, integrating selected clinical variables with a quantitative CT Rad-score using RSF showed promising numerical discrimination and risk-stratification performance. These findings suggest that clinical and quantitative imaging information may provide complementary prognostic information after AE-IIM-ILD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liyu He"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanrong Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingping Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Kai Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuo Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaqi Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuhan Bian"
    },
    {
      "affs": [
        0
      ],
      "name": "Youmin Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenwang Jin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eqahfc89hppcc.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1917500",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672662/?tool=EBI",
  "id": "eqahfc89hppcc",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13672662",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis"
    ]
  ],
  "openalex": "W7215711856",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672662/pdf/?tool=EBI",
  "pmcid": "PMC13672662",
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/eqahfc89hppcc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:25Z",
      "native_id": "PMC:PMC13672662",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13672662"
    },
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1917500",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1917500/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Clinical variables and quantitative CT radiomics for mortality risk stratification after acute exacerbation of idiopathic inflammatory myopathy-associated interstitial lung disease",
  "title_text": "Clinical variables and quantitative CT radiomics for mortality risk stratification after acute exacerbation of idiopathic inflammatory myopathy-associated interstitial lung disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:15Z",
  "url": "https://research.draconitic.com/paper/eqahfc89hppcc",
  "venue": "Frontiers in immunology",
  "versions": []
}