{
  "abstract": "Contrast agents capable of being injected and cured in situ within the vasculature are required for angiography based on X-ray microcomputed tomography (µ-CT) for pathophysiology of biopsies or postmortem. In this study, we developed a contrast agent based on highly-concentrated methanolic dispersion of NiAl-type layered double hydroxide nanoparticles (NiAl-LDH NPs) for X-ray µ-CT imaging of vasculature. We optimized the synthesis conditions of the constituent NiAl-LDH NPs, with particular attention to drying conditions and dispersion media selection. The formulated contrast agent achieved a particle concentration >30 wt%, a curing time of ∼30 min, and low viscosity (<100 mPa s). These properties enabled successful perfusion into small vessels and capillaries giving excellent X-ray attenuation following setting without tissue maceration. Consequently, this enabled reliable vessel identification and segmentation using simple intensity-based approaches giving a robust approach to accelerated tissue screening.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Materials Science, Graduate School of Engineering, Osaka Metropolitan University 1-1 Gakuen-cho, Naka-ku, Sakai Osaka 599-8531 Japan tokudome@omu.ac.jp.",
    "Center for Oral, Clinical, and Translational Sciences, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London London UK gowsihan.poologasundarampillai@kcl.ac.uk.",
    "Maternal and Fetal Health Research Centre, School of Medical Sciences, University of Manchester Manchester UK.",
    "Rosalind Franklin Institute, Harwell Science and Innovation Campus, Fermi Ave Didcot OX11 0QS UK.",
    "SAGA Light Source, 8-7 Yayoigaoka Tosu Saga 841-0005 Japan.",
    "Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima Hiroshima 739-8527 Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yosuke Ando"
    },
    {
      "affs": [
        0
      ],
      "name": "Sota Shimizu"
    },
    {
      "affs": [
        1
      ],
      "name": "Gowsihan Poologasundarampillai"
    },
    {
      "affs": [
        2
      ],
      "name": "Paul Brownbill"
    },
    {
      "affs": [
        2
      ],
      "name": "Angelos Evangelinos"
    },
    {
      "affs": [
        3
      ],
      "name": "Michele Darrow"
    },
    {
      "affs": [
        3
      ],
      "name": "Avery Pennington"
    },
    {
      "affs": [
        1
      ],
      "name": "Achintha Kondarage"
    },
    {
      "affs": [
        4
      ],
      "name": "Akio Yoneyama",
      "orcid": "0000-0001-6925-6723"
    },
    {
      "affs": [
        5
      ],
      "name": "Naoki Tarutani",
      "orcid": "0000-0003-0696-8082"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsushi Nakahira"
    },
    {
      "affs": [
        0
      ],
      "name": "Yasuaki Tokudome",
      "orcid": "0000-0001-8644-6385"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eqfp6pvycda95.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ma00511j",
  "fulltext_url": "https://europepmc.org/articles/PMC13662904",
  "id": "eqfp6pvycda95",
  "issns": [
    "2633-5409"
  ],
  "landing_url": "https://europepmc.org/article/MED/42877626",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Layered Double Hydroxides Synthesis and Applications"
    ]
  ],
  "openalex": "W7221532623",
  "pdf_url": "https://pubs.rsc.org/ma/article-pdf/doi/10.1039/D6MA00511J/14871441/d6ma00511j.pdf",
  "pmcid": "PMC13662904",
  "pmid": "42877626",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eqfp6pvycda95.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42877626",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42877626"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Layered Double Hydroxides Synthesis and Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "X-ray µ-CT contrast agents employing highly-concentrated low-viscosity layered double hydroxide nanoparticles for high-resolution imaging of vasculature.",
  "title_text": "X-ray µ-CT contrast agents employing highly-concentrated low-viscosity layered double hydroxide nanoparticles for high-resolution imaging of vasculature.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/eqfp6pvycda95",
  "venue": "Materials advances",
  "versions": []
}