{
  "abstract": "Loop-mediated isothermal amplification (LAMP) offers a promising alternative to PCR for low-resource settings, but practical barriers remain. For example there is often the need for reliable electricity, precision heating equipment, and cold-chain storage of reagents. Here, we describe a rudimentary but functional platform that integrates (i) a non-electric, chemically driven water bath capable of sustaining LAMP-relevant temperatures and (ii) lyophilized LAMP assays compatible with simple sample inputs such as diluted saliva or oral rinse. We demonstrate successful LAMP amplification under multiple heating configurations, including a thermos-based chemical bath and field-mimicking setups. This work provides proof-of-concept for a low-cost, portable molecular diagnostic workflow that minimizes infrastructure requirements while maintaining analytical performance.",
  "abstract_shown": true,
  "affiliations": [
    "University of Texas at Austin"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "K. K. Grandhe"
    },
    {
      "affs": [
        0
      ],
      "name": "T. E. Riedel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eqm5jgrpy20cc.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.06.26365637",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.11.06.26365637v1.full",
  "id": "eqm5jgrpy20cc",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.11.06.26365637v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "infectious diseases"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.11.06.26365637v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eqm5jgrpy20cc.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:22:41Z",
      "native_id": "10.64898/2026.11.06.26365637",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.11.06.26365637v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:infectious diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Electricity Free LAMP: A Protocol for Loop-Mediated Isothermal Amplification Using an Exothermic Chemical Reaction and Lyophilized Reagents",
  "title_text": "Electricity Free LAMP: A Protocol for Loop-Mediated Isothermal Amplification Using an Exothermic Chemical Reaction and Lyophilized Reagents",
  "type": "preprint",
  "updated_at": "2026-11-10T00:22:41Z",
  "url": "https://research.draconitic.com/paper/eqm5jgrpy20cc",
  "venue": "medRxiv",
  "versions": []
}