{
  "abstract": "Background\n\nPlatelet transfusion can be lifesaving in dogs with severe thrombocytopenia and hemorrhage, but platelet products are limited by short shelf life and contamination risk. Cold-stored platelets (CSP) may provide a practical alternative, but in vivo hemostatic efficacy in dogs is unknown.Hypothesis/objectives\n\nEvaluate the clinical hemostatic efficacy and safety of CSP transfusions in thrombocytopenic dogs.Animals\n\nTwenty-four thrombocytopenic dogs from a veterinary teaching hospital population that received CSP transfusions between March 2022 and October 2024.Methods\n\nRetrospective cohort study. Medical records of dogs receiving platelet concentrate stored at 4 °C for up to 21 days were reviewed. Hemorrhage severity was assessed using a modified Daily Canine Bleeding Assessment Tool (DOGiBAT) score before transfusion and at 1 and 4 h post-transfusion. Primary outcomes included change in bleeding score, clinical response, transfusion reactions, and survival to discharge.Results\n\nTwenty-four dogs received 27 CSP transfusions. Mean pre-transfusion platelet count was 23 × 103/μL (range, 2-107 × 103/μL) and mean post-transfusion count was 28 × 103/μL (range, 2-100 × 103/μL; P = .84). Mean DOGiBAT score decreased from 3.15 ± 2.4 at baseline to 2.21 ± 2.1 at 4 (mean change, -0.94; P = .002). Clinical improvement occurred in 19 of 27 transfusions (70%). No transfusion reactions were documented. Nineteen of 24 dogs (79%) survived to discharge.Conclusions and clinical importance\n\nCold-stored platelets were well-tolerated and associated with decreased bleeding severity in thrombocytopenic dogs, supporting CSP as a practical platelet transfusion option for clinical hemostatic support.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, WA 99163 United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shannon A Monaco",
      "orcid": "0009-0006-5285-6953"
    },
    {
      "affs": [
        0
      ],
      "name": "Jillian M Haines",
      "orcid": "0000-0002-8066-838X"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarah C Guess",
      "orcid": "0000-0003-1472-343X"
    },
    {
      "affs": [
        0
      ],
      "name": "Sybil M Fiedler",
      "orcid": "0009-0005-4338-7449"
    },
    {
      "affs": [
        0
      ],
      "name": "K Jane Wardrop",
      "orcid": "0000-0002-2029-817X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eqydpfyhpx9rq.bib",
  "cited_by": 0,
  "doi": "10.1093/jvimsj/aalag262",
  "fulltext_url": "https://europepmc.org/articles/PMC13693600",
  "id": "eqydpfyhpx9rq",
  "issns": [
    "0891-6640",
    "1939-1676"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912657",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2704|Blood transfusion and management"
    ]
  ],
  "openalex": "W7223414293",
  "pdf_url": "https://europepmc.org/articles/PMC13693600?pdf=render",
  "pmcid": "PMC13693600",
  "pmid": "42912657",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/eqydpfyhpx9rq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42912657",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912657"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2704|Blood transfusion and management",
      "subfield": "general"
    }
  ],
  "title": "The use of cold-stored platelets to provide hemostasis in dogs with thrombocytopenia.",
  "title_text": "The use of cold-stored platelets to provide hemostasis in dogs with thrombocytopenia.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/eqydpfyhpx9rq",
  "venue": "Journal of veterinary internal medicine",
  "versions": []
}