{
  "abstract": "Objective: To analyze the epidemiological characteristics and coinfection of SARS-CoV-2 and influenza virus among acute respiratory infection (ARI) cases in Sichuan Province from August 2024 to July 2026.\n\nMethods: Using 24-month surveillance data from seven national respiratory pathogen sentinel hospitals in Sichuan Province, respiratory specimens were tested for both viruses by multiplex real-time RT-PCR. Positive rates and 95% CIs were calculated by the Wilson score method; group comparisons used the chi-square test or Fisher’s exact test; independent risk factors were identified by multivariable logistic regression.\n\nResults: A total of 22,436 valid cases were included. The positive rates of SARS-CoV-2, influenza virus, and coinfection were 4.39% (95% CI: 4.13–4.67%), 9.83% (95% CI: 9.45–10.22%), and 0.05% (95% CI: 0.03–0.09%), respectively. The two viruses peaked in different seasons, with SARS-CoV-2 in summer and influenza in winter–spring. Summer was an independent risk factor for SARS-CoV-2 infection (OR = 23.88, 95% CI: 17.04–33.46); children aged 6–14 years had the highest risk of influenza (OR = 2.52, 95% CI: 2.21–2.88). The observed coinfection rate was far lower than the expectation under independent circulation of the two viruses (0.43%; O/E = 0.11, p < 0.001), indicating a negative (asynchronous) association rather than synergy, with marked spatiotemporal clustering.\n\nConclusion: SARS-CoV-2 and influenza virus circulated in pronounced seasonal asynchrony in Sichuan Province, with no population-level evidence of synergy; coinfection was rare but locally clustered, supporting differentiated prevention and control strategies. Given the hospital-based sentinel design, extrapolation to the whole province should be made with caution.",
  "abstract_shown": true,
  "affiliations": [
    "Sichuan Center for Disease Control and Prevention"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fengmiao Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xingyu Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Lijun Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhirui Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuang Dong"
    },
    {
      "affs": [
        0
      ],
      "name": "Chongkun Xiao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/er53cemvggmpk.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1961515",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727529/?tool=EBI",
  "id": "er53cemvggmpk",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1961515/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Respiratory viral infections research"
    ]
  ],
  "openalex": "W7223041811",
  "pdf_url": "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1961515/pdf",
  "pmcid": "PMC13727529",
  "pmid": "42978624",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/er53cemvggmpk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:24Z",
      "native_id": "10.3389/fpubh.2026.1961515",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1961515/full"
    },
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13727529",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727529"
    },
    {
      "first_seen": "2026-11-06T12:23:23Z",
      "native_id": "PMC13727529",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fpubh.2026.1961515"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Respiratory viral infections research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Analysis of multiplex pathogen sentinel surveillance results of SARS-CoV-2 and influenza virus in Sichuan Province, 2024–2026",
  "title_text": "Analysis of multiplex pathogen sentinel surveillance results of SARS-CoV-2 and influenza virus in Sichuan Province, 2024–2026",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:42Z",
  "url": "https://research.draconitic.com/paper/er53cemvggmpk",
  "venue": "Frontiers in Public Health",
  "versions": []
}