{
  "abstract": "The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates, as well as mitotic DNA intertwinements, yet how its diverse activities are regulated remains unclear. Here, we identify key determinants of stable assembly of the BTRR complex on ultrafine DNA bridges (UFBs). We reveal that the RMI1-RMI2 subcomplex acts as a molecular reader of hydrophobic-rich short linear motifs (SLiMs) embedded within PICH and FANCM, thereby providing a conserved mechanism for engaging distinct Superfamily2 DNA translocases during chromosome segregation and DNA repair. During UFB resolution, SLiM binding stabilises the PICH-BTRR complex assembly and supports essential interactions among BLM, PICH, and DNA. Persistent PICH-BTRR complex association post-mitosis would compromise interphase DNA damage responses and is prevented by active PICH nuclear exclusion. Our findings define the molecular basis of UFB-binding complex assembly and highlight its spatiotemporal control required to specialise BTRR complex functions.",
  "abstract_shown": true,
  "affiliations": [
    "Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, United Kingdom"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "U. Aliyaskarova"
    },
    {
      "name": "O. Ozer"
    },
    {
      "name": "M. Sumon"
    },
    {
      "name": "E. Karanika"
    },
    {
      "name": "A. Crncec"
    },
    {
      "name": "Z. Kozik"
    },
    {
      "name": "T. Roumeliotis"
    },
    {
      "name": "J. Choudhary"
    },
    {
      "name": "M. Fernandez-Casanas"
    },
    {
      "name": "M. Day"
    },
    {
      "name": "A. W. Oliver"
    },
    {
      "name": "J. Pines"
    },
    {
      "affs": [
        0
      ],
      "name": "K.-L. Chan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ercnffxve249b.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.10.750333",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750333v1.full",
  "id": "ercnffxve249b",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750333v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1312|DNA Repair Mechanisms"
    ]
  ],
  "openalex": "W7212449474",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750333v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ercnffxve249b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:56Z",
      "native_id": "10.64898/2026.09.10.750333",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750333v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "Mechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges",
  "title_text": "Mechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:56Z",
  "url": "https://research.draconitic.com/paper/ercnffxve249b",
  "venue": "bioRxiv",
  "versions": []
}