{
  "abstract": "Cutaneous pain-sensing nociceptive neurons can directly recognize pathogen invasion and modulate the resulting host immune response. Neuronal recognition of C. albicans cell wall components is necessary and sufficient for optimal protective local type-17 immune responses. We now report a parallel neuroimmune pathway in which extracellular ATP (eATP) released from C. albicans and keratinocytes activates nonpeptidergic neurons, including Mas-related G protein-coupled receptor D (Mrgprd)-expressing NP1 neurons, through the P2X3 ATP receptor. Ablation of NP1 neurons or P2rx3 increased C. albicans colony-forming units (CFUs), but the induction of type-17 responses was unaffected. Rather, transcriptomic analysis revealed an alteration in genes and pathways associated with barrier repair. P2rx3-/- mice showed increased wound size and transepidermal water loss associated with a delay in barrier repair following C. albicans infection or abrasion. These data identify a neuroimmune circuit where nonpeptidergic neurons sense epidermal damage or infection through eATP and P2X3, resulting in augmented barrier repair and thus host defense.",
  "abstract_shown": true,
  "affiliations": [
    "Departments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.",
    "Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.",
    "Department of Immunology and Computational Immunogenomics (CIG) Core, University of Pittsburgh, Pittsburgh, PA 15213, USA.",
    "Department of Pharmacology, School of Medicine, Tongji University, Shanghai, China.",
    "Department of Biology, Georgetown University, Washington, DC 20057, USA.",
    "Division of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.",
    "Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15261, USA.",
    "Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.",
    "Lead contact."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tara N Edwards"
    },
    {
      "affs": [
        0
      ],
      "name": "Chien-Sin Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Richard T Cattley"
    },
    {
      "affs": [
        2
      ],
      "name": "Isha Mehta"
    },
    {
      "affs": [
        2
      ],
      "name": "Ogechukwu Ezenwa"
    },
    {
      "affs": [
        3
      ],
      "name": "Shiqun Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lindsay M McKendrick"
    },
    {
      "affs": [
        0
      ],
      "name": "Sydney-Lam N Nguyen"
    },
    {
      "affs": [
        0
      ],
      "name": "Anjelica J Ferguson"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrew W Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Paul Yifan Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Alicia R Mathers"
    },
    {
      "affs": [
        5
      ],
      "name": "Sarah L Gaffen"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Kathryn M Albers"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "H Richard Koerber"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Brian M Davis"
    },
    {
      "affs": [
        1
      ],
      "name": "William F Hawse"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jishnu Das"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Daniel H Kaplan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/erexmk8g0zb43.bib",
  "cited_by": 0,
  "doi": "10.1016/j.cpblue.2026.100103",
  "fulltext_url": "https://europepmc.org/articles/PMC13750726",
  "id": "erexmk8g0zb43",
  "issns": [
    "3051-3839"
  ],
  "landing_url": "https://europepmc.org/article/MED/43011974",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1314|Adenosine and Purinergic Signaling"
    ]
  ],
  "openalex": "W7203829031",
  "pdf_url": "https://europepmc.org/articles/PMC13750726?pdf=render",
  "pmcid": "PMC13750726",
  "pmid": "43011974",
  "published": "2026-08-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/erexmk8g0zb43.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:25:13Z",
      "native_id": "MED:43011974",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43011974"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1314|Adenosine and Purinergic Signaling",
      "subfield": "physiology"
    }
  ],
  "title": "Cutaneous nonpeptidergic neurons sense extracellular ATP to augment barrier repair and C. albicans host defense.",
  "title_text": "Cutaneous nonpeptidergic neurons sense extracellular ATP to augment barrier repair and C. albicans host defense.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T15:20:23Z",
  "url": "https://research.draconitic.com/paper/erexmk8g0zb43",
  "venue": "Cell press blue",
  "versions": []
}